Sichuan jingshen weisheng (Dec 2021)

Sertraline combined with low-dose aripiprazole in the treatment of obsessive-compulsive disorder in children and adolescents: a randomized controlled study

  • Wu Hailong,
  • Zhang Zhenqing,
  • Lu Dali

DOI
https://doi.org/10.11886/scjsws20210428001
Journal volume & issue
Vol. 34, no. 6
pp. 529 – 532

Abstract

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ObjectiveTo investigate the efficacy and safety of sertraline combined with low-dose aripiprazole in the treatment of obsessive-compulsive disorder in children and adolescents.MethodsA total of 62 cases pediatric patients aged 9~16 years who attended the outpatient clinic of a psychiatric hospital in Xiamen from June 2018 to May 2020 and met the diagnostic criteria of International Classification of Diseases, tenth edition (ICD-10) for obsessive-compulsive disorder were enrolled in the study. The selected children were randomly classified into two groups for different treatments. Control group (n=30) received sertraline monotherapy, and study group (n=32) received sertraline combined with low-dose aripiprazole treatment. At the baseline and the end of the 2nd, 4th, 8th and 12th weeks of treatment, children were assessed using Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS) and Treatment Emergent Symptoms Scale (TESS). Thereafter, the clinical efficacy and adverse reactions were compared between two groups.ResultsThe compulsive behavior dimensional score of CY-BOCS of study group was lower than that of control group at end of the 2nd and 4th weeks of treatment (t=-2.083, -2.176, P<0.05). At the end of the 2nd week of treatment, the effective rate was 40.63% in study group, which was significantly higher than 3.33% in control group (χ2=12.317, P<0.01). By the end of the 12th weeks of treatment, the incidence rate of side effects yielded no statistical difference between two groups (χ2=1.608, P=0.205).ConclusionCompared with sertraline monotherapy, its combination with low-dose aripiprazole treatment can effectively accelerate the improvement of clinical symptoms in childrenand adolescents with obsessive-compulsive disorder, while the combination therapy and sertraline monotherapy have equivalent safety.

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