Nature Communications (Sep 2019)

Assisted reproductive technologies are associated with limited epigenetic variation at birth that largely resolves by adulthood

  • Boris Novakovic,
  • Sharon Lewis,
  • Jane Halliday,
  • Joanne Kennedy,
  • David P. Burgner,
  • Anna Czajko,
  • Bowon Kim,
  • Alexandra Sexton-Oates,
  • Markus Juonala,
  • Karin Hammarberg,
  • David J. Amor,
  • Lex W. Doyle,
  • Sarath Ranganathan,
  • Liam Welsh,
  • Michael Cheung,
  • John McBain,
  • Robert McLachlan,
  • Richard Saffery

DOI
https://doi.org/10.1038/s41467-019-11929-9
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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Use of Assisted Reproductive Technologies (ART) is increasing globally but their impact on long term health remains unclear. Here the authors show that ART-conceived individuals show variation in epigenetic profile at birth that largely resolves by adulthood, with no evidence of an impact on long term outcomes.