Skin γδ T Cells and Their Function in Wound Healing

Wengang Hu; Wengang Hu; Ruoyu Shang; Ruoyu Shang; Jiacai Yang; Jiacai Yang; Cheng Chen; Cheng Chen; Zhihui Liu; Zhihui Liu; Guangping Liang; Guangping Liang; Weifeng He; Weifeng He; Gaoxing Luo; Gaoxing Luo

doi:10.3389/fimmu.2022.875076

Frontiers in Immunology (Apr 2022)

Skin γδ T Cells and Their Function in Wound Healing

Wengang Hu,
Wengang Hu,
Ruoyu Shang,
Ruoyu Shang,
Jiacai Yang,
Jiacai Yang,
Cheng Chen,
Cheng Chen,
Zhihui Liu,
Zhihui Liu,
Guangping Liang,
Guangping Liang,
Weifeng He,
Weifeng He,
Gaoxing Luo,
Gaoxing Luo

Affiliations

Wengang Hu: State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China
Wengang Hu: Chongqing Key Laboratory for Disease Proteomics, Chongqing, China
Ruoyu Shang: State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China
Ruoyu Shang: Chongqing Key Laboratory for Disease Proteomics, Chongqing, China
Jiacai Yang: State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China
Jiacai Yang: Chongqing Key Laboratory for Disease Proteomics, Chongqing, China
Cheng Chen: State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China
Cheng Chen: Chongqing Key Laboratory for Disease Proteomics, Chongqing, China
Zhihui Liu: State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China
Zhihui Liu: Chongqing Key Laboratory for Disease Proteomics, Chongqing, China
Guangping Liang: State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China
Guangping Liang: Chongqing Key Laboratory for Disease Proteomics, Chongqing, China
Weifeng He: State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China
Weifeng He: Chongqing Key Laboratory for Disease Proteomics, Chongqing, China
Gaoxing Luo: State Key Laboratory of Trauma, Burn and Combined Injury, Institute of Burn Research, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China
Gaoxing Luo: Chongqing Key Laboratory for Disease Proteomics, Chongqing, China

DOI: https://doi.org/10.3389/fimmu.2022.875076
Journal volume & issue: Vol. 13

Abstract

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For the skin immune system, γδ T cells are important components, which help in defensing against damage and infection of skin. Compared to the conventional αβ T cells, γδ T cells have their own differentiation, development and activation characteristics. In adult mice, dendritic epidermal T cells (DETCs), Vγ4 and Vγ6 γδ T cells are the main subsets of skin, the coordination and interaction among them play a crucial role in wound repair. To get a clear overview of γδ T cells, this review synopsizes their derivation, development, colonization and activation, and focuses their function in acute and chronic wound healing, as well as the underlining mechanism. The aim of this paper is to provide cues for the study of human epidermal γδ T cells and the potential treatment for skin rehabilitation.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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