Nature Communications (Oct 2017)

Selective binding of choline by a phosphate-coordination-based triple helicate featuring an aromatic box

  • Chuandong Jia,
  • Wei Zuo,
  • Dong Yang,
  • Yanming Chen,
  • Liping Cao,
  • Radu Custelcean,
  • Jiří Hostaš,
  • Pavel Hobza,
  • Robert Glaser,
  • Yao-Yu Wang,
  • Xiao-Juan Yang,
  • Biao Wu

DOI
https://doi.org/10.1038/s41467-017-00915-8
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 8

Abstract

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The choline-binding protein ChoX exhibits a synergistic dual-site binding mode that allows it to discriminate choline over structural analogues. Here, the authors design a biomimetic triple anion helicate receptor whose selectivity for choline arises from a similar binding mechanism.