Sorafenib and sunitinib: A dermatologist′s perspective

Abstract

Sorafenib and sunitinib are inhibitors of tumor angiogenesis have recently generated curiosity regarding its role in cutaneous toxicities, which has severely affected the daily activities resulting in interruption or dose modification of therapy in renal cell carcinoma and hepatocellular carcinomas. We discuss the pathophysiology, adverse cutaneous effects and their grading, potential high risk factors, role of gene polymorphism, critical period of hand-foot skin reaction development and their management.

Keywords

• Burgdorf reaction
• hand-foot skin reaction
• palmar-plantar erythrodysesthesia