Nature Communications (Sep 2021)
Measuring kinetics and metastatic propensity of CTCs by blood exchange between mice
- Bashar Hamza,
- Alex B. Miller,
- Lara Meier,
- Max Stockslager,
- Sheng Rong Ng,
- Emily M. King,
- Lin Lin,
- Kelsey L. DeGouveia,
- Nolawit Mulugeta,
- Nicholas L. Calistri,
- Haley Strouf,
- Christina Bray,
- Felicia Rodriguez,
- William A. Freed-Pastor,
- Christopher R. Chin,
- Grissel C. Jaramillo,
- Megan L. Burger,
- Robert A. Weinberg,
- Alex K. Shalek,
- Tyler Jacks,
- Scott R. Manalis
Affiliations
- Bashar Hamza
- Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology
- Alex B. Miller
- David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Lara Meier
- David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Max Stockslager
- David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Sheng Rong Ng
- David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Emily M. King
- David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Lin Lin
- David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Kelsey L. DeGouveia
- David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Nolawit Mulugeta
- David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Nicholas L. Calistri
- David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Haley Strouf
- David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Christina Bray
- David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Felicia Rodriguez
- David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- William A. Freed-Pastor
- David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Christopher R. Chin
- David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Grissel C. Jaramillo
- David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Megan L. Burger
- David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Robert A. Weinberg
- David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Alex K. Shalek
- David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Tyler Jacks
- David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- Scott R. Manalis
- David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology
- DOI
- https://doi.org/10.1038/s41467-021-25917-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Current methods for acquiring dissemination kinetics of rare circulating tumor cells (CTCs) that form metastases have several limitations. Here, the authors show an approach for measuring endogenous CTC kinetics by continuously exchanging CTC-containing blood between un-anesthetized, tumor-bearing mice and healthy, tumor-free counterparts.
