World Allergy Organization Journal (Feb 2020)
A WAO — ARIA — GA2LEN consensus document on molecular-based allergy diagnosis (PAMD@): Update 2020
- Ignacio J. Ansotegui,
- Giovanni Melioli,
- Giorgio Walter Canonica,
- R. Maximiliano Gómez,
- Erika Jensen-Jarolim,
- Motohiro Ebisawa,
- Olga Luengo,
- Luis Caraballo,
- Giovanni Passalacqua,
- Lars K. Poulsen,
- Eleonora Savi,
- Torsten Zuberbier,
- Elisa Villa,
- John Oppenheimer,
- Riccardo Asero,
- Jonathan Bernstein,
- Jean Bousquet,
- Victoria Cardona,
- Lindo Cox,
- Pascal Demoly,
- Fatima Ferreira,
- Pedro Giavina Bianchi,
- Sandra Gonzalez Diaz,
- Thilo Jakob,
- Luciana Kase Tanno,
- Jorg Kleine-Tebbe,
- Michael Levin,
- Bryan Martin,
- Paolo Maria Matricardi,
- Olga Patricia Monge Ortega,
- Mario Morais Almeida,
- Carlos Nunes,
- José Antonio Ortega Martell,
- Harald Renz,
- Nelson Rosário Filho,
- Philip Rouadi,
- Alessia Ruiba,
- Hugh Sampson,
- Mario Sánchez Borges,
- Enrico Scala,
- Peter Schmid-Grendelmeier,
- Gian-Enrico Senna,
- Juan Carlos Sisul,
- Mimi L.K. Tang,
- Rudolf Valenta,
- Marianne van Hage,
- Gary W.K. Wong,
- Anahí Yáñez
Affiliations
- Ignacio J. Ansotegui
- Hospital Quironsalud Bizkaia, Bilbao-Erandio, Spain; Corresponding author.
- Giovanni Melioli
- Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy; Corresponding author.
- Giorgio Walter Canonica
- Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, Milan, Italy; Personalized Medicine, Asthma and Allergy, Humanitas Research Hospital, Rozzano, Milan, Italy; Corresponding author.
- R. Maximiliano Gómez
- Universidad Católica de Salta, Fundación Ayre, Buenos Aires, Argentina
- Erika Jensen-Jarolim
- Institute for Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, The Interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University Vienna, Vienna, Austria
- Motohiro Ebisawa
- Clinical Research Center for Allergy and Rheumatology, Sagamihara National Hospital, Sagamihara, Kanagawa, Japan
- Olga Luengo
- Allergy Section, Department of Internal Medicine, Vall d’Hebron University Hospital, Barcelona, Spain
- Luis Caraballo
- Institute for Immunological Research, University of Cartagena, Cartagena, Colombia
- Giovanni Passalacqua
- Allergy and Respiratory Diseases, IRCCS Policlinico San Martino, University of Genoa, Genoa, Italy
- Lars K. Poulsen
- Gentofte University Hospital, Lab for Allergology, Allergy Clinic, Hellerup, Denmark
- Eleonora Savi
- Ospedale Civile, Gossolengo, PC, Italy
- Torsten Zuberbier
- Campus Charite Mitte, Klinik fur Dermatologie & Allergologie, Berlin, Germany
- Elisa Villa
- ASL 3 Liguria, Pneumology Department, Villa Scassi Hospital, Genova, Italy
- John Oppenheimer
- Pulmonary & Allergy Associates, Denville, NJ, USA
- Riccardo Asero
- Clinica San Carlo, Ambulatorio di Allergologia, Paderno Dugnano, Italy
- Jonathan Bernstein
- Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA
- Jean Bousquet
- MACVIA-France, Montpellier, France; INSERM, Villejuif, France; Université Versailles St-Quentin-en-Yvelines, Montigny le Bretonneux, France; Euforea, Brussels, Belgium; CHU Montpellier, France
- Victoria Cardona
- Universitat Autónoma de Barcelona, Hospital Universitario Vall d'Hebron, Servicio de Medicina Interna, Sección de Alergología, Barcelona, Spain
- Lindo Cox
- University of Miami School of Medicine, Nova Southeastern University School of Osteopathic Medicine, Fort Lauderdale, FL, USA
- Pascal Demoly
- Allergy Unit, Département de Pneumologie et Addictologie, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, Montpellier, France; Sorbonne Universités, Paris, France
- Fatima Ferreira
- Department of Biosciences, University of Salzburg, Salzburg, Austria
- Pedro Giavina Bianchi
- Clinical Immunology and Allergy Division, University of Sao Paulo, Sao Paulo, Brazil
- Sandra Gonzalez Diaz
- Universidad Autónoma de Nuevo León, Hospital Universitario, Monterrey, Nuevo León, Mexico
- Thilo Jakob
- Department of Dermatology and Allergology, Experimental Dermatology and Allergy Research Group, University Medical Center Gießen-Marburg, Justus Liebig University Gießen, Gießen, Germany; Allergy Research Group, Department of Dermatology, Medical Center, University of Freiburg, Freiburg, Germany
- Luciana Kase Tanno
- University Hospital, Montpellier, France; Sorbonne Université, Hospital Sírio Libanês, Paris, France; University of São Paulo, São Paulo, Brazil
- Jorg Kleine-Tebbe
- Allergy & Asthma Center Westend, Outpatient Clinic and Research Center, Berlin, Germany
- Michael Levin
- Division of Allergy, Department of Paediatrics, Red Cross Children’s Hospital, University of Cape Town, South Africa
- Bryan Martin
- The Ohio State University, Medicine and Pediatrics, Columbus, OH, USA
- Paolo Maria Matricardi
- Department of Pediatric Pneumology, Immunology and Intensive Care Medicine, Charité Medical University, Berlin, Germany
- Olga Patricia Monge Ortega
- Department of Allergy, San Juan de Dios Hospital, University of Costa Rica, San José, Costa Rica
- Mario Morais Almeida
- Centro de Alergia dos Hospitais CUF, Lisbon, Portugal
- Carlos Nunes
- Centro de Imunoalergologia do Algarve, Portimão, Portugal
- José Antonio Ortega Martell
- School of Medicine, Autonomous University of Hidalgo State, Pachuca, Hidalgo, Mexico
- Harald Renz
- University Hospital GI & MR GmbH, Institute of Laboratory Medicine & Pathology, Standort Marburg, Marburg, Germany
- Nelson Rosário Filho
- University of Parana, Curitiba, PR, Brazil
- Philip Rouadi
- Department of Otolaryngology-Head and Neck Surgery, American University of Beirut, School of Medicine and Medical Center, Beirut, Lebanon
- Alessia Ruiba
- Department of Experimental Medicine, University of Genova, Genova, Italy
- Hugh Sampson
- Division of Pediatric Allergy and Immunology, Icahn School of Medicine at Mount Sinai, New York, NY, USA
- Mario Sánchez Borges
- Clínica El Ávila, Caracas, Venezuela
- Enrico Scala
- Experimental Allergy Unit, Istituto Dermopatico dell'Immacolata, Rome, Italy
- Peter Schmid-Grendelmeier
- Allergy Unit, Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
- Gian-Enrico Senna
- Ospedale Civile Maggiore, Lungoadige Cangrande 12, Verona, Italy
- Juan Carlos Sisul
- Allergy & Asthma Institute, Asuncion, Paraguay
- Mimi L.K. Tang
- Royal Children’s Hospital, Department of Allergy & Immunology, Parkville, Victoria, Australia
- Rudolf Valenta
- Division of Immunopathology, Department of Pathophysiology and Allergy Research, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria; NRC Institute of Immunology FMBA of Russia, Moscow, Russia; Laboratory of Immunopathology, Department of Clinical Immunology and Allergy, Sechenov First Moscow State Medical University, Moscow, Russia
- Marianne van Hage
- Department of Medicine Solna, Immunology and Allergy Unit, Karolinska Institutet, Stockholm, Sweden; Karolinska University Hospital, Stockholm, Sweden
- Gary W.K. Wong
- Department of Paediatrics, The Chinese University of Hong Kong, Hong Kong, China
- Anahí Yáñez
- Investigaciones en Alergia y Enfermedades Respiratorias (INAER), Buenos Aires, Argentina
- Journal volume & issue
-
Vol. 13,
no. 2
Abstract
Precision allergy molecular diagnostic applications (PAMD@) is increasingly entering routine care. Currently, more than 130 allergenic molecules from more than 50 allergy sources are commercially available for in vitro specific immunoglobulin E (sIgE) testing. Since the last publication of this consensus document, a great deal of new information has become available regarding this topic, with over 100 publications in the last year alone. It thus seems quite reasonable to publish an update. It is imperative that clinicians and immunologists specifically trained in allergology keep abreast of the new and rapidly evolving evidence available for [email protected]@ may initially appear complex to interpret; however, with increasing experience, the information gained provides relevant information for the allergist. This is especially true for food allergy, Hymenoptera allergy, and for the selection of allergen immunotherapy. Nevertheless, all sIgE tests, including PAMD@, should be evaluated within the framework of a patient's clinical history, because allergen sensitization does not necessarily imply clinical relevant allergies. Keywords: Diagnosis, Molecular allergy, Cross reactivity, Panallergen, Specific IgE, PAMD@
