A study on risk factors for mild vascular cognitive impairment in patients with lacunar infarct

Abstract

Objective To study the risk factors for vascular cognitive impairment (VCI) after lacunar infarct (LACI). Methods A total of 138 patients with LACI were evaluated by Montreal Cognitive Assessment (MoCA), and divided into normal cognitive function group (normal, N = 55), mild cognitive impairment (MCI) group (mild, N = 73) and severe cognitive impairment group (severe, N = 10). Univariate and backward multivariate Logistic regression analysis were used to screen the risk factors for VCI after LACI. Results Logistic regression analysis showed that infarct in critical site (OR = 1.179, 95% CI: 0.870-2.472; P = 0.012) and white matter hyperintensity (WMH) Grade 3-4 (OR = 2.005, 95% CI: 0.910-4.502; P = 0.024) were independent risk factors for VCI in patients with LACI. Conclusions VCI in patients with LACI is related to multiple factors, in which infarct in critical site and WMH Grade 3-4 are independent risk factors. DOI: 10.3969/j.issn.1672-6731.2016.11.010

Keywords

• Brain infarction
• Cognition disorders
• Risk factors
• Regression analysis