Oncoviruses: Induction of cancer development and metastasis by increasing anoikis resistance
Zahra Sobhi Amjad,
Ali Shojaeian,
Javid Sadri Nahand,
Mobina Bayat,
Mohammad Taghizadieh,
Mosayeb Rostamian,
Farhad Babaei,
Mohsen Moghoofei
Affiliations
Zahra Sobhi Amjad
Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Ali Shojaeian
Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Javid Sadri Nahand
Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Mobina Bayat
Infectious and Tropical Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Mohammad Taghizadieh
Department of Pathology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Mosayeb Rostamian
Nosocomial Infections Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
Farhad Babaei
Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran
Mohsen Moghoofei
Department of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah, Iran; Infectious Diseases Research Center, Health Research Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran; Corresponding author. Infectious Diseases Research Center, Health Research Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
The phenomenon of cell death is a vital aspect in the regulation of aberrant cells such as cancer cells. Anoikis is a kind of cell death that occurs when cells get separated from the extracellular matrix. Some cancer cells can inhibit anoikis in order to progress metastasis. One of the key variables that might be implicated in anoikis resistance (AR) is viral infections. The most important viruses involved in this process are Epstein-Barr virus, human papillomavirus, hepatitis B virus, human herpes virus 8, human T-cell lymphotropic virus type 1, and hepatitis C virus. A better understanding of how carcinogenic viruses suppress anoikis might be helpful in developing an effective treatment for virus-associated cancers. In the current study, we review the role of the mentioned viruses and their gene products in anoikis inhibition.
