Combined use of statins and inhibitors of arginase l-norvaline for correcting endotoksin-inducing endotelial dysfunction

Abstract

Using of the combined use of non-selective inhibitor of arginase L-norvaline with simvastatin, atorvastatin, rosuvastatin and rosuvastatin nanopartikulirovanny on background modeling endotoxin-induced disease, the introduction of strain 603 Staphylococcusaureus shows ekdotelio- and cardioprotective effects, manifested in preventing the proliferation of coefficient of endothelial dysfunction (CED), adrenoreactivity, maintaining myocardial reserve and normalization values of biochemical markers (Total NO, Expression of eNOS, C-reactive protein, IL-6, TNF). Thus, combination therapy found no additive effect of drugs.

Keywords

• эндотелиальная дисфункция
• статины
• l-норвалин
• эндотоксин
• endothelial dysfunction
• statins
• l-norvalin
• endotoxin