Dose-related adaptive reconstruction of DMN in isoflurane administration: a study in the rat

Fengru Guo; Yuqin Li; Zhaoxin Jian; Yan Cui; Wenhui Gong; Airui Li; Wei Jing; Peng Xu; Ke Chen; Daqing Guo; Dezhong Yao; Yang Xia

doi:10.1186/s12871-023-02153-6

BMC Anesthesiology (Jun 2023)

Dose-related adaptive reconstruction of DMN in isoflurane administration: a study in the rat

Fengru Guo,
Yuqin Li,
Zhaoxin Jian,
Yan Cui,
Wenhui Gong,
Airui Li,
Wei Jing,
Peng Xu,
Ke Chen,
Daqing Guo,
Dezhong Yao,
Yang Xia

Affiliations

Fengru Guo: Department of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China
Yuqin Li: Department of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China
Zhaoxin Jian: Department of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China
Yan Cui: Department of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China
Wenhui Gong: Department of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China
Airui Li: Department of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China
Wei Jing: Department of Physiology, School of Basic Medicine and Tongji Medical College, Huazhong University of Science and Technology
Peng Xu: Department of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China
Ke Chen: Department of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China
Daqing Guo: Department of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China
Dezhong Yao: Department of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China
Yang Xia: Department of Neurosurgery, MOE Key Lab for Neuroinformation, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China

DOI: https://doi.org/10.1186/s12871-023-02153-6
Journal volume & issue: Vol. 23, no. 1
pp. 1 – 12

Abstract

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Abstract Background The anesthetic states are accompanied by functional alterations. However, the dose-related adaptive alterations in the higher-order network under anesthesia, e. g. default mode network (DMN), are poorly revealed. Methods We implanted electrodes in brain regions of the rat DMN to acquire local field potentials to investigate the perturbations produced by anesthesia. Relative power spectral density, static functional connectivity (FC), fuzzy entropy of dynamic FC, and topological features were computed from the data. Results The results showed that adaptive reconstruction was induced by isoflurane, exhibiting reduced static and stable long-range FC, and altered topological features. These reconstruction patterns were in a dose-related fashion. Conclusion These results might impart insights into the neural network mechanisms underlying anesthesia and suggest the potential of monitoring the depth of anesthesia based on the parameters of DMN.

Published in BMC Anesthesiology

ISSN: 1471-2253 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Surgery: Anesthesiology
Website: https://bmcanesthesiol.biomedcentral.com

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