Ventricular Thrombus Formation Caused by Subendomyocardial Inflammation in Eosinophilic Granulomatosis With Polyangiitis

Naoyuki Takahashi, MD; Takenori Ikoma, MD, PhD; Atsushi Sakamoto, MD, PhD; Kenichiro Suwa, MD, PhD; Mayu Fujihiro, MD; Kumiko Shimoyama, MD, PhD; Hayato Ohtani, MD, PhD; Satoshi Baba, MD, PhD; Noriyoshi Ogawa, MD, PhD; Yuichiro Maekawa, MD, PhD

JACC: Case Reports (May 2024)

Ventricular Thrombus Formation Caused by Subendomyocardial Inflammation in Eosinophilic Granulomatosis With Polyangiitis

Naoyuki Takahashi, MD,
Takenori Ikoma, MD, PhD,
Atsushi Sakamoto, MD, PhD,
Kenichiro Suwa, MD, PhD,
Mayu Fujihiro, MD,
Kumiko Shimoyama, MD, PhD,
Hayato Ohtani, MD, PhD,
Satoshi Baba, MD, PhD,
Noriyoshi Ogawa, MD, PhD,
Yuichiro Maekawa, MD, PhD

Affiliations

Naoyuki Takahashi, MD: Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan
Takenori Ikoma, MD, PhD: Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan
Atsushi Sakamoto, MD, PhD: Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan; Address for correspondence: Dr Atsushi Sakamoto, Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu 431-3192, Japan.
Kenichiro Suwa, MD, PhD: Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan
Mayu Fujihiro, MD: Department of Diagnostic Pathology, Hamamatsu University School of Medicine, Hamamatsu, Japan
Kumiko Shimoyama, MD, PhD: Division of Rheumatology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan
Hayato Ohtani, MD, PhD: Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan
Satoshi Baba, MD, PhD: Department of Diagnostic Pathology, Hamamatsu University School of Medicine, Hamamatsu, Japan
Noriyoshi Ogawa, MD, PhD: Division of Rheumatology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan
Yuichiro Maekawa, MD, PhD: Division of Cardiology, Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan

Journal volume & issue: Vol. 29, no. 10
p. 102321

Abstract

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Cardiac involvement of eosinophilic granulomatosis with polyangiitis is a rare but life-threatening complication. We present a case of eosinophilic granulomatosis with polyangiitis with moderately impaired ventricular function forming a ventricular thrombus. Pathological assessment of endomyocardial biopsy specimen revealed aggregated eosinophils in the subendocardium, suggesting ventricular endothelial damage leading to thrombus formation.

Published in JACC: Case Reports

ISSN: 2666-0849 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.journals.elsevier.com/jacc-case-reports

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Abstract

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