Nature Communications (Nov 2017)
Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma
- Jose Mario Gonzalez-Meljem,
- Scott Haston,
- Gabriela Carreno,
- John R. Apps,
- Sara Pozzi,
- Christina Stache,
- Grace Kaushal,
- Alex Virasami,
- Leonidas Panousopoulos,
- Seyedeh Neda Mousavy-Gharavy,
- Ana Guerrero,
- Mamunur Rashid,
- Nital Jani,
- Colin R. Goding,
- Thomas S. Jacques,
- David J. Adams,
- Jesus Gil,
- Cynthia L. Andoniadou,
- Juan Pedro Martinez-Barbera
Affiliations
- Jose Mario Gonzalez-Meljem
- Developmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child Health
- Scott Haston
- Developmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child Health
- Gabriela Carreno
- Developmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child Health
- John R. Apps
- Developmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child Health
- Sara Pozzi
- Developmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child Health
- Christina Stache
- Developmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child Health
- Grace Kaushal
- Developmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child Health
- Alex Virasami
- Department of Histopathology, Great Ormond Street Hospital for Children
- Leonidas Panousopoulos
- Developmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child Health
- Seyedeh Neda Mousavy-Gharavy
- Developmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child Health
- Ana Guerrero
- Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, Du Cane Road
- Mamunur Rashid
- Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton
- Nital Jani
- GOSgene, Genetics and Genomic Medicine, UCL Institute of Child Health
- Colin R. Goding
- Ludwig Institute for Cancer Research, Oxford University, Old Road Campus, Headington
- Thomas S. Jacques
- Developmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child Health
- David J. Adams
- Experimental Cancer Genetics, Wellcome Trust Sanger Institute, Hinxton
- Jesus Gil
- Cell Proliferation Group, MRC Clinical Sciences Centre, Imperial College London, Hammersmith Campus, Du Cane Road
- Cynthia L. Andoniadou
- Centre for Craniofacial and Regenerative Biology, King’s College London, Guy’s Hospital, Floor 27 Tower Wing
- Juan Pedro Martinez-Barbera
- Developmental Biology and Cancer Programme, Birth Defects Research Centre, UCL Institute of Child Health
- DOI
- https://doi.org/10.1038/s41467-017-01992-5
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 14
Abstract
Senescent cells can promote tumour progression through the activation of a senescenceassociated secretory phenotype (SASP). Here, the authors show that SASP activation is associated with non-cell autonomous cell transformation and tumour initiation in an in vivo model of adamantinomatous craniopharyngioma.
