Nature Communications (Sep 2020)

Versatile live-cell activity analysis platform for characterization of neuronal dynamics at single-cell and network level

  • Xinyue Yuan,
  • Manuel Schröter,
  • Marie Engelene J. Obien,
  • Michele Fiscella,
  • Wei Gong,
  • Tetsuhiro Kikuchi,
  • Aoi Odawara,
  • Shuhei Noji,
  • Ikuro Suzuki,
  • Jun Takahashi,
  • Andreas Hierlemann,
  • Urs Frey

DOI
https://doi.org/10.1038/s41467-020-18620-4
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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Current methods of neuronal network imaging cannot be used for continuous, long-term functional recordings. Here, the authors present a dual-mode high-density microelectrode array, which can simultaneously record in full-frame and high-signal-to-noise modes for label-free electrophysiological measurements.