Effect of β3‐adrenergic receptor gene polymorphism and lifestyle on overweight Japanese rural residents: A cross‐sectional study

Akinori Hara; Phat Minh Nguyen; Hiromasa Tsujiguchi; Masaharu Nakamura; Yohei Yamada; Keita Suzuki; Fumihiko Suzuki; Tomoko Kasahara; Oanh Kim Pham; Haruki Nakamura; Yasuhiro Kambayashi; Yukari Shimizu; Thao Thi Thu Nguyen; Sakae Miyagi; Takayuki Kannon; Takehiro Sato; Kazuyoshi Hosomichi; Atsushi Tajima; Hiroyuki Nakamura

doi:10.1002/osp4.560

Obesity Science & Practice (Apr 2022)

Effect of β3‐adrenergic receptor gene polymorphism and lifestyle on overweight Japanese rural residents: A cross‐sectional study

Akinori Hara,
Phat Minh Nguyen,
Hiromasa Tsujiguchi,
Masaharu Nakamura,
Yohei Yamada,
Keita Suzuki,
Fumihiko Suzuki,
Tomoko Kasahara,
Oanh Kim Pham,
Haruki Nakamura,
Yasuhiro Kambayashi,
Yukari Shimizu,
Thao Thi Thu Nguyen,
Sakae Miyagi,
Takayuki Kannon,
Takehiro Sato,
Kazuyoshi Hosomichi,
Atsushi Tajima,
Hiroyuki Nakamura

Affiliations

Akinori Hara: Department of Hygiene and Public Health Faculty of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Ishikawa Japan
Phat Minh Nguyen: Department of Hygiene and Public Health Faculty of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Ishikawa Japan
Hiromasa Tsujiguchi: Department of Hygiene and Public Health Faculty of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Ishikawa Japan
Masaharu Nakamura: Department of Hygiene and Public Health Faculty of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Ishikawa Japan
Yohei Yamada: Department of Hygiene and Public Health Faculty of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Ishikawa Japan
Keita Suzuki: Department of Hygiene and Public Health Faculty of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Ishikawa Japan
Fumihiko Suzuki: Department of Hygiene and Public Health Faculty of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Ishikawa Japan
Tomoko Kasahara: Department of Hygiene and Public Health Faculty of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Ishikawa Japan
Oanh Kim Pham: Department of Hygiene and Public Health Faculty of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Ishikawa Japan
Haruki Nakamura: Department of Hygiene and Public Health Faculty of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Ishikawa Japan
Yasuhiro Kambayashi: Department of Public Health Faculty of Veterinary Medicine Okayama University of Science Imabari Ehime Japan
Yukari Shimizu: Department of Nursing Faculty of Health Sciences Komatsu University Komatsu Ishikawa Japan
Thao Thi Thu Nguyen: Department of Epidemiology Faculty of Public Health Haiphong University of Medicine and Pharmacy Hai Phong Vietnam
Sakae Miyagi: Division of Biostatistics Innovative Clinical Research Center Kanazawa University Kanazawa Ishikawa Japan
Takayuki Kannon: Department of Bioinformatics and Genomics Faculty of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Ishikawa Japan
Takehiro Sato: Department of Bioinformatics and Genomics Faculty of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Ishikawa Japan
Kazuyoshi Hosomichi: Department of Bioinformatics and Genomics Faculty of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Ishikawa Japan
Atsushi Tajima: Department of Bioinformatics and Genomics Faculty of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Ishikawa Japan
Hiroyuki Nakamura: Department of Hygiene and Public Health Faculty of Medicine Institute of Medical, Pharmaceutical and Health Sciences Kanazawa University Kanazawa Ishikawa Japan

DOI: https://doi.org/10.1002/osp4.560
Journal volume & issue: Vol. 8, no. 2
pp. 199 – 207

Abstract

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Abstract Objectives The β3‐adrenergic receptor (ADRB3) gene polymorphism has been implicated in obesity. Therefore, the contribution of ADRB3 Trp64Arg polymorphism to obesity‐related indicators was investigated, taking into account the lifestyle‐related factors in a Japanese rural population. Methods A total of 600 Japanese adults aged ≥40 years in a population‐based cohort study were analyzed. The ADRB3 polymorphism was determined using peripheral blood samples. Associations between genotype and body mass index (BMI), waist circumference (WC), and body fat (BF) percentage were examined, adjusting for lifestyle‐related factors, including daily nutrient intake. Results The frequency of Arg64 allele carriers was 36%. There was no significant difference in BMI, WC, or BF between the groups with or without the Trp64Arg polymorphism. Multivariable logistic regression analysis showed that the Trp64Arg polymorphism was not associated with these three indicators, but lifestyle factors including physical inactivity, higher energy and sodium consumption, and less animal protein intake were significantly related to increased WC and BF percentages. Conclusions The Trp64Arg polymorphism of ADRB3 gene did not contribute to increased BMI, WC, or BF. However, lifestyle‐related factors impacted these indicators in middle‐aged and older Japanese individuals living in rural areas.

Published in Obesity Science & Practice

ISSN: 2055-2238 (Online)
Publisher: Wiley
Country of publisher: United States
LCC subjects: Medicine: Internal medicine
Website: https://onlinelibrary.wiley.com/journal/20552238

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