Dynamic Strategic Bond Analysis Yields a Ten-Step Synthesis of 20-nor-Salvinorin A, a Potent κ‑OR Agonist

• Jeremy J. Roach,
• Yusuke Sasano,
• Cullen L. Schmid,
• Saheem Zaidi,
• Vsevolod Katritch,
• Raymond C. Stevens,
• Laura M. Bohn,
• Ryan A. Shenvi

Affiliations

Jeremy J. Roach

Department of Chemistry, The Scripps Research Institute, La Jolla, California, United States

Yusuke Sasano

Department of Chemistry, The Scripps Research Institute, La Jolla, California, United States

Cullen L. Schmid

Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, Florida, United States

Saheem Zaidi

Departments of Chemistry and Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, California, United States

Vsevolod Katritch

Departments of Chemistry and Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, California, United States

Raymond C. Stevens

Departments of Chemistry and Biological Sciences, Bridge Institute, University of Southern California, Los Angeles, California, United States

Laura M. Bohn

Departments of Molecular Therapeutics and Neuroscience, The Scripps Research Institute, Jupiter, Florida, United States

Ryan A. Shenvi

Department of Chemistry, The Scripps Research Institute, La Jolla, California, United States