Associations of exposure to phthalate with serum uric acid and hyperuricemia risk, and the mediating role of systemic immune inflammation

Zhiping Niu; Tianyi Chen; Zhizhou Duan; Shichao Han; Yifan Shi; Wenyuan Yu; Shuang Du; Hao Tang; Wenpu Shao; Jin Sun; Han Chen; Yunfei Cai; Yanyi Xu; Zhuohui Zhao

Ecotoxicology and Environmental Safety (Nov 2024)

Associations of exposure to phthalate with serum uric acid and hyperuricemia risk, and the mediating role of systemic immune inflammation

Zhiping Niu,
Tianyi Chen,
Zhizhou Duan,
Shichao Han,
Yifan Shi,
Wenyuan Yu,
Shuang Du,
Hao Tang,
Wenpu Shao,
Jin Sun,
Han Chen,
Yunfei Cai,
Yanyi Xu,
Zhuohui Zhao

Affiliations

Zhiping Niu: Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China
Tianyi Chen: Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China
Zhizhou Duan: Preventive Health Service, Jiangxi Provincial People's Hospital, Nanchang, China
Shichao Han: Department of Urology, Xijing Hospital, Air Force Medical University, Xi'an, China
Yifan Shi: Department of Psychiatry, Xijing Hospital, Air Force Medical University, Xi'an, China
Wenyuan Yu: School & Hospital of Stomatology, Wuhan University, Wuhan, China
Shuang Du: Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China
Hao Tang: Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China
Wenpu Shao: Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China
Jin Sun: Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China
Han Chen: Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China
Yunfei Cai: Section of General Management, Shanghai Environment Monitoring Center, Shanghai, China; Corresponding authors.
Yanyi Xu: Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China; Corresponding authors.
Zhuohui Zhao: Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China; Shanghai Typhoon Institute/CMA, Shanghai Key Laboratory of Meteorology and Health, Shanghai, China; IRDR International Center of Excellence on Risk Interconnectivity and Governance on Weather/Climate Extremes Impact and Public Health, Fudan University, Shanghai, China; Corresponding author at: Department of Environmental Health, School of Public Health, Fudan University, Shanghai, China.

Journal volume & issue: Vol. 287
p. 117269

Abstract

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Background: Previous studies found that urinary phthalates (PAEs) metabolites may be associated with increased serum uric acid concentration and hyperuricemia risk. However, no population-based study has investigated the underlying biological mechanisms. Methods: This nationwide cross-sectional study analyzed the data from the National Health and Nutrition Examination Survey (NHANES) 2003–2018. Urinary PAEs metabolites were measured and 8 PAEs metabolites (MCPP, MECPP, MEHHP, MEOHP, MBzP, MiBP, MBP, and MEP) were incorporated into the analysis. Serum uric acid was determined and hyperuricemia cases were identified. Multi-variable generalized linear model, exposure-response (E-R) function and weighted quantile sum (WQS) regression were utilized to investigate the relationships of PAEs metabolites with serum uric acid concentration and hyperuricemia risk. Systemic immune inflammation (SII) was assessed using the SII index and its mediation effects were explored using causal mediation effect model. Results: Data from 10,633 US adults in the NHANES 2003–2018 was analyzed. Except for MEP, individual PAEs metabolite and total PAEs metabolites were associated with increased serum uric acid concentration and hyperuricemia risk. E-R function of PAEs metabolites with serum uric acid concentration and the risk of hyperuricemia showed significantly positive associations with most curves in a nearly linear relationship. WQS regression showed that the mixture of PAEs metabolites was related to elevated serum uric acid and hyperuricemia risk, and MBzP was identified as the most contributing PAEs metabolite. The causal mediation effect model found that SII significantly mediated the relationships of PAEs metabolites with serum uric acid and hyperuricemia risk. Conclusion: Individual and mixture of urinary PAEs metabolites were associated with increased serum uric acid concentration and the risk of hyperuricemia. MBzP exhibited the highest contribution to the overall effects. SII alteration may be an important biological mechanism underlining the impact of PAEs metabolites on serum uric acid concentration and hyperuricemia risk.

Published in Ecotoxicology and Environmental Safety

ISSN: 0147-6513 (Print); 1090-2414 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Technology: Environmental technology. Sanitary engineering: Environmental pollution; Geography. Anthropology. Recreation: Environmental sciences
Website: https://www.journals.elsevier.com/ecotoxicology-and-environmental-safety

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