Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts

Nicola Ferrari; Romana Ranftl; Ievgeniia Chicherova; Neil D. Slaven; Emad Moeendarbary; Aaron J. Farrugia; Maxine Lam; Maria Semiannikova; Marie C. W. Westergaard; Julia Tchou; Luca Magnani; Fernando Calvo

doi:10.1038/s41467-018-07987-0

Nature Communications (Jan 2019)

Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts

Nicola Ferrari,
Romana Ranftl,
Ievgeniia Chicherova,
Neil D. Slaven,
Emad Moeendarbary,
Aaron J. Farrugia,
Maxine Lam,
Maria Semiannikova,
Marie C. W. Westergaard,
Julia Tchou,
Luca Magnani,
Fernando Calvo

Affiliations

Nicola Ferrari: Tumour Microenvironment Team, Division of Cancer Biology, The Institute of Cancer Research
Romana Ranftl: Tumour Microenvironment Team, Division of Cancer Biology, The Institute of Cancer Research
Ievgeniia Chicherova: Tumour Microenvironment Team, Division of Cancer Biology, The Institute of Cancer Research
Neil D. Slaven: Department of Surgery and Cancer, Imperial College London
Emad Moeendarbary: Department of Mechanical Engineering, University College London
Aaron J. Farrugia: Tumour Microenvironment Team, Division of Cancer Biology, The Institute of Cancer Research
Maxine Lam: Tumour Microenvironment Team, Division of Cancer Biology, The Institute of Cancer Research
Maria Semiannikova: Tumour Microenvironment Team, Division of Cancer Biology, The Institute of Cancer Research
Marie C. W. Westergaard: Center for Cancer Immune Therapy, Department of Hematology, Herlev Hospital, University of Copenhagen
Julia Tchou: Abramson Cancer Center and the Department of Surgery, Perelman School of Medicine, University of Pennsylvania
Luca Magnani: Department of Surgery and Cancer, Imperial College London
Fernando Calvo: Tumour Microenvironment Team, Division of Cancer Biology, The Institute of Cancer Research

DOI: https://doi.org/10.1038/s41467-018-07987-0
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 17

Abstract

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It is unclear how specific signalling pathways are coordinated to generate pathologically activated cancer associated fibroblasts (CAFs). Here, Ferrari et al show that stromal expression of Dickkopf-3 (DKK3) associates with aggressive tumours. DKK3 is a HSF-1 effector that activates β-catenin and YAP/TAZ, and DKK3-driven YAP/TAZ activation regulates the pro-tumorigenic behaviour of CAFs.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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