Nature Communications (May 2022)
Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells
Abstract
The transcription factors, Runx1 and Runx2 are critical embryonically for generation of HSCs and osteoblasts, respectively. Here the authors show that adult mice lacking Runx1 and Runx2 in HSC-supporting CAR cells displayed an increase in fibrosis with reduced HSCs in bone marrow.