Nature Communications (May 2022)

Runx1 and Runx2 inhibit fibrotic conversion of cellular niches for hematopoietic stem cells

  • Yoshiki Omatsu,
  • Shota Aiba,
  • Tomonori Maeta,
  • Kei Higaki,
  • Kazunari Aoki,
  • Hitomi Watanabe,
  • Gen Kondoh,
  • Riko Nishimura,
  • Shu Takeda,
  • Ung-il Chung,
  • Takashi Nagasawa

DOI
https://doi.org/10.1038/s41467-022-30266-y
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

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The transcription factors, Runx1 and Runx2 are critical embryonically for generation of HSCs and osteoblasts, respectively. Here the authors show that adult mice lacking Runx1 and Runx2 in HSC-supporting CAR cells displayed an increase in fibrosis with reduced HSCs in bone marrow.