Marrubium vulgare L. Leave Extract: Phytochemical Composition, Antioxidant and Wound Healing Properties
Bédis Amri,
Emanuela Martino,
Francesca Vitulo,
Federica Corana,
Leila Bettaieb-Ben Kaâb,
Marta Rui,
Daniela Rossi,
Michela Mori,
Silvia Rossi,
Simona Collina
Affiliations
Bédis Amri
Département de Biologie, Faculté des Sciences de Tunis el Manar, Unité de recherche ‘Nutrition et métabolismes azoté et protéines de stress’ (99 UR/09-20), 1002 Tunis, Tunisia
Emanuela Martino
Department of Earth and Environmental Sciences, University of Pavia, Via S. Epifanio 14, 27100 Pavia, Italy
Francesca Vitulo
Indena S.p.A., Via Don Minzoni, 6, 20090 Settala, Italy
Federica Corana
Centro Grandi Strumenti (CGS), University of Pavia, Via Bassi 21, 27100 Pavia, Italy
Leila Bettaieb-Ben Kaâb
Département de Biologie, Faculté des Sciences de Tunis el Manar, Unité de recherche ‘Nutrition et métabolismes azoté et protéines de stress’ (99 UR/09-20), 1002 Tunis, Tunisia
Marta Rui
Department of Drug Sciences, Medicinal Chemistry section, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy
Daniela Rossi
Department of Drug Sciences, Medicinal Chemistry section, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy
Michela Mori
Department of Drug Sciences, Medicinal Chemistry section, University of Pavia, Viale Taramelli 12, 27100 Pavia, Italy
Silvia Rossi
Centre for Health Technologies (CHT), University of Pavia, Viale Taramelli 12, Pavia 27100, Italy
Simona Collina
Centre for Health Technologies (CHT), University of Pavia, Viale Taramelli 12, Pavia 27100, Italy
Several factors contribute in wound generation, e.g., accidental traumas or surgery, and in certain cases, this dermal injury may have a devastating outcome. When skin damage occurs, the human body puts in place a sophisticated choreography, which involves numerous repairing processes to restore physiological conditions. Nevertheless, natural healing mechanisms are ineffective towards chronic or non-healing wounds and thus, therapeutic strategies may represent the only beneficial alternative to counteract these tissue insults. Over the years, numerous studies showed the great potential of plants in promoting wound healing, by virtue of their high contents in antioxidant species. These compounds trigger a molecular cascade that collimate into the promotion of reparative processes. In this article, we report on the potential effect on wound healing of Marrubium vulgare L., a medicinal plant well known for several pharmaceutical activities. To this aim, the methanolic extract was prepared and subjected to a phytochemical investigation, quantifying the amount of marrubiin via NMR and drawing the phytochemical fingerprint via high performance liquid chromatography—ultra violet/photodiode-array detection-electrospray/mass (HPLC-UV/PAD-ESI/MS) analysis. Lastly, the antioxidant properties and wound healing potential have been evaluated.
