Nature Communications (Dec 2017)
Mutational patterns in chemotherapy resistant muscle-invasive bladder cancer
- David Liu,
- Philip Abbosh,
- Daniel Keliher,
- Brendan Reardon,
- Diana Miao,
- Kent Mouw,
- Amaro Weiner-Taylor,
- Stephanie Wankowicz,
- Garam Han,
- Min Yuen Teo,
- Catharine Cipolla,
- Jaegil Kim,
- Gopa Iyer,
- Hikmat Al-Ahmadie,
- Essel Dulaimi,
- David Y. T. Chen,
- R. Katherine Alpaugh,
- Jean Hoffman-Censits,
- Levi A. Garraway,
- Gad Getz,
- Scott L. Carter,
- Joaquim Bellmunt,
- Elizabeth R. Plimack,
- Jonathan E. Rosenberg,
- Eliezer M. Van Allen
Affiliations
- David Liu
- Dana-Farber Cancer Institute
- Philip Abbosh
- Fox Chase Cancer Center
- Daniel Keliher
- Dana-Farber Cancer Institute
- Brendan Reardon
- Dana-Farber Cancer Institute
- Diana Miao
- Dana-Farber Cancer Institute
- Kent Mouw
- Dana-Farber Cancer Institute
- Amaro Weiner-Taylor
- Broad Institute of Harvard and MIT
- Stephanie Wankowicz
- Dana-Farber Cancer Institute
- Garam Han
- Dana-Farber Cancer Institute
- Min Yuen Teo
- Memorial Sloan Kettering Cancer Center
- Catharine Cipolla
- Memorial Sloan Kettering Cancer Center
- Jaegil Kim
- Broad Institute of Harvard and MIT
- Gopa Iyer
- Memorial Sloan Kettering Cancer Center
- Hikmat Al-Ahmadie
- Memorial Sloan Kettering Cancer Center
- Essel Dulaimi
- Fox Chase Cancer Center
- David Y. T. Chen
- Fox Chase Cancer Center
- R. Katherine Alpaugh
- Fox Chase Cancer Center
- Jean Hoffman-Censits
- Thomas Jefferson University Hospital
- Levi A. Garraway
- Dana-Farber Cancer Institute
- Gad Getz
- Broad Institute of Harvard and MIT
- Scott L. Carter
- Dana-Farber Cancer Institute
- Joaquim Bellmunt
- Dana-Farber Cancer Institute
- Elizabeth R. Plimack
- Fox Chase Cancer Center
- Jonathan E. Rosenberg
- Memorial Sloan Kettering Cancer Center
- Eliezer M. Van Allen
- Dana-Farber Cancer Institute
- DOI
- https://doi.org/10.1038/s41467-017-02320-7
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 11
Abstract
The impact of cisplatin-based chemotherapy on tumor genomes is complex. Here, the authors study matched pre- and post-chemotherapy primary samples in muscle-invasive bladder cancer, finding a cisplatin-based mutational signature, and highlighting the impact of intratumor heterogeneity on survival.
