Nature Communications (Feb 2017)

Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling

  • Tsai-Yi Lu,
  • Jennifer M. MacDonald,
  • Lukas J. Neukomm,
  • Amy E. Sheehan,
  • Rachel Bradshaw,
  • Mary A. Logan,
  • Marc R. Freeman

DOI
https://doi.org/10.1038/ncomms14355
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 9

Abstract

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The engulfment receptor Draper is known to promote glial activation and phagocytosis of debris upon axonal injury. Luet al. identify TNF receptor associated factor 4 (TRAF4) as a binding partner of Draper, and map out the signalling cascade leading to reactive gliosis in Drosophila.