Molecular determinants of transforming growth factor beta-1 action on human glioblastoma cells

Abstract

Background. Increased expression of transforming growth factor beta-1 (TGF-β1) in malignant brain tumors promotes cancer cells survival enhancing their growth, migration, invasion, angiogenesis, immune system suppression.Objective is to study molecular mechanisms of TGF-β1 action on U87 human glioblastoma cells by means of proteomic high-resolution massspectrometry.Results. We have identified intracell signal pathways responsible for TGF-β1 involvement in malignant gliomas oncogenesis including differential expressed proteins of tight cell junctions, focal adhesion, histone deacetylases, heat shock, S100 family.Conclusions. Important patterns are determined that could be used for the development of new approaches for detection of glioblastoma metastasis candidate markers and potential therapy targets of this decease.

Keywords

• трансформирующий фактор роста бета-1
• мультиформная глиобластома
• протеом
• масс-спектрометрия
• эпителиально-мезенхимальный переход
• фокальная адгезия
• плотные межклеточные контакты