Nature Communications (Jul 2020)
Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival
- Syed H. Zaidi,
- Tabitha A. Harrison,
- Amanda I. Phipps,
- Robert Steinfelder,
- Quang M. Trinh,
- Conghui Qu,
- Barbara L. Banbury,
- Peter Georgeson,
- Catherine S. Grasso,
- Marios Giannakis,
- Jeremy B. Adams,
- Elizabeth Alwers,
- Efrat L. Amitay,
- Richard T. Barfield,
- Sonja I. Berndt,
- Ivan Borozan,
- Hermann Brenner,
- Stefanie Brezina,
- Daniel D. Buchanan,
- Yin Cao,
- Andrew T. Chan,
- Jenny Chang-Claude,
- Charles M. Connolly,
- David A. Drew,
- Alton Brad Farris,
- Jane C. Figueiredo,
- Amy J. French,
- Charles S. Fuchs,
- Levi A. Garraway,
- Steve Gruber,
- Mark A. Guinter,
- Stanley R. Hamilton,
- Sophia Harlid,
- Lawrence E. Heisler,
- Akihisa Hidaka,
- John L. Hopper,
- Wen-Yi Huang,
- Jeroen R. Huyghe,
- Mark A. Jenkins,
- Paul M. Krzyzanowski,
- Mathieu Lemire,
- Yi Lin,
- Xuemei Luo,
- Elaine R. Mardis,
- John D. McPherson,
- Jessica K. Miller,
- Victor Moreno,
- Xinmeng Jasmine Mu,
- Reiko Nishihara,
- Nickolas Papadopoulos,
- Danielle Pasternack,
- Michael J. Quist,
- Adilya Rafikova,
- Emma E. G. Reid,
- Eve Shinbrot,
- Brian H. Shirts,
- Lincoln D. Stein,
- Cherie D. Teney,
- Lee Timms,
- Caroline Y. Um,
- Bethany Van Guelpen,
- Megan Van Tassel,
- Xiaolong Wang,
- David A. Wheeler,
- Christina K. Yung,
- Li Hsu,
- Shuji Ogino,
- Andrea Gsur,
- Polly A. Newcomb,
- Steven Gallinger,
- Michael Hoffmeister,
- Peter T. Campbell,
- Stephen N. Thibodeau,
- Wei Sun,
- Thomas J. Hudson,
- Ulrike Peters
Affiliations
- Syed H. Zaidi
- Ontario Institute for Cancer Research
- Tabitha A. Harrison
- Public Health Sciences Division, Fred Hutchinson Cancer Research Centre
- Amanda I. Phipps
- Public Health Sciences Division, Fred Hutchinson Cancer Research Centre
- Robert Steinfelder
- Public Health Sciences Division, Fred Hutchinson Cancer Research Centre
- Quang M. Trinh
- Ontario Institute for Cancer Research
- Conghui Qu
- Public Health Sciences Division, Fred Hutchinson Cancer Research Centre
- Barbara L. Banbury
- Public Health Sciences Division, Fred Hutchinson Cancer Research Centre
- Peter Georgeson
- Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville
- Catherine S. Grasso
- Public Health Sciences Division, Fred Hutchinson Cancer Research Centre
- Marios Giannakis
- Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School
- Jeremy B. Adams
- Ontario Institute for Cancer Research
- Elizabeth Alwers
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Efrat L. Amitay
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Richard T. Barfield
- Public Health Sciences Division, Fred Hutchinson Cancer Research Centre
- Sonja I. Berndt
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Ivan Borozan
- Ontario Institute for Cancer Research
- Hermann Brenner
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Stefanie Brezina
- Institute of Cancer Research, Department of Medicine I, Medical University of Vienna
- Daniel D. Buchanan
- Colorectal Oncogenomics Group, Department of Clinical Pathology, The University of Melbourne, Parkville
- Yin Cao
- Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School
- Andrew T. Chan
- Broad Institute of MIT and Harvard
- Jenny Chang-Claude
- Division of Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Charles M. Connolly
- Public Health Sciences Division, Fred Hutchinson Cancer Research Centre
- David A. Drew
- Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School
- Alton Brad Farris
- Pathology and Laboratory Medicine, Emory University School of Medicine
- Jane C. Figueiredo
- Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center
- Amy J. French
- Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic
- Charles S. Fuchs
- Yale Cancer Center
- Levi A. Garraway
- Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School
- Steve Gruber
- Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
- Mark A. Guinter
- Behavioral and Epidemiology Research Group, American Cancer Society
- Stanley R. Hamilton
- City of Hope Comprehensive Cancer Center
- Sophia Harlid
- Department of Radiation Sciences, Oncology Unit, Umeå University
- Lawrence E. Heisler
- Ontario Institute for Cancer Research
- Akihisa Hidaka
- Public Health Sciences Division, Fred Hutchinson Cancer Research Centre
- John L. Hopper
- University of Melbourne Centre for Cancer Research, Victorian Comprehensive Cancer Centre
- Wen-Yi Huang
- Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health
- Jeroen R. Huyghe
- Public Health Sciences Division, Fred Hutchinson Cancer Research Centre
- Mark A. Jenkins
- Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne
- Paul M. Krzyzanowski
- Ontario Institute for Cancer Research
- Mathieu Lemire
- Ontario Institute for Cancer Research
- Yi Lin
- Public Health Sciences Division, Fred Hutchinson Cancer Research Centre
- Xuemei Luo
- Ontario Institute for Cancer Research
- Elaine R. Mardis
- Institute for Genomic Medicine, Nationwide Children’s Hospital and The Ohio State University College of Medicine
- John D. McPherson
- Ontario Institute for Cancer Research
- Jessica K. Miller
- Ontario Institute for Cancer Research
- Victor Moreno
- Oncology Data Analytics Program, Catalan Institute of Oncology and ONCOBELL Program, IDIBELL
- Xinmeng Jasmine Mu
- Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School
- Reiko Nishihara
- Department of Oncologic Pathology, Dana-Farber Cancer Institute and Harvard Medical School
- Nickolas Papadopoulos
- Department of Oncology, Sidney Kimmel Comprehensive Cancer Center
- Danielle Pasternack
- Ontario Institute for Cancer Research
- Michael J. Quist
- Public Health Sciences Division, Fred Hutchinson Cancer Research Centre
- Adilya Rafikova
- Ontario Institute for Cancer Research
- Emma E. G. Reid
- Ontario Institute for Cancer Research
- Eve Shinbrot
- Human Genome Sequencing Centre, Baylor College of Medicine
- Brian H. Shirts
- Department of Laboratory Medicine, University of Washington, University of Washington Medical Center
- Lincoln D. Stein
- Ontario Institute for Cancer Research
- Cherie D. Teney
- Ontario Institute for Cancer Research
- Lee Timms
- Ontario Institute for Cancer Research
- Caroline Y. Um
- Behavioral and Epidemiology Research Group, American Cancer Society
- Bethany Van Guelpen
- Department of Radiation Sciences, Oncology Unit, Umeå University
- Megan Van Tassel
- Ontario Institute for Cancer Research
- Xiaolong Wang
- Public Health Sciences Division, Fred Hutchinson Cancer Research Centre
- David A. Wheeler
- Human Genome Sequencing Centre, Baylor College of Medicine
- Christina K. Yung
- Ontario Institute for Cancer Research
- Li Hsu
- Public Health Sciences Division, Fred Hutchinson Cancer Research Centre
- Shuji Ogino
- Broad Institute of MIT and Harvard
- Andrea Gsur
- Institute of Cancer Research, Department of Medicine I, Medical University of Vienna
- Polly A. Newcomb
- Public Health Sciences Division, Fred Hutchinson Cancer Research Centre
- Steven Gallinger
- Ontario Institute for Cancer Research
- Michael Hoffmeister
- Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ)
- Peter T. Campbell
- Behavioral and Epidemiology Research Group, American Cancer Society
- Stephen N. Thibodeau
- Division of Laboratory Genetics, Department of Laboratory Medicine and Pathology, Mayo Clinic
- Wei Sun
- Public Health Sciences Division, Fred Hutchinson Cancer Research Centre
- Thomas J. Hudson
- Ontario Institute for Cancer Research
- Ulrike Peters
- Public Health Sciences Division, Fred Hutchinson Cancer Research Centre
- DOI
- https://doi.org/10.1038/s41467-020-17386-z
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Large scale sequencing study is of paramount importance to unravel the heterogeneity of colorectal cancer. Here, the authors sequenced 205 cancer genes in more than 2000 tumours and identified additional mutated driver genes, determined that mutational burden and specific mutations in TP53 are associated with survival odds.
