miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers

Anne-Marie Givel; Yann Kieffer; Alix Scholer-Dahirel; Philemon Sirven; Melissa Cardon; Floriane Pelon; Ilaria Magagna; Géraldine Gentric; Ana Costa; Claire Bonneau; Virginie Mieulet; Anne Vincent-Salomon; Fatima Mechta-Grigoriou

doi:10.1038/s41467-018-03348-z

Nature Communications (Mar 2018)

miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers

Anne-Marie Givel,
Yann Kieffer,
Alix Scholer-Dahirel,
Philemon Sirven,
Melissa Cardon,
Floriane Pelon,
Ilaria Magagna,
Géraldine Gentric,
Ana Costa,
Claire Bonneau,
Virginie Mieulet,
Anne Vincent-Salomon,
Fatima Mechta-Grigoriou

Affiliations

Anne-Marie Givel: Institut Curie, Stress and Cancer Laboratory, Equipe labelisée Ligue Nationale Contre le Cancer, PSL Research University
Yann Kieffer: Institut Curie, Stress and Cancer Laboratory, Equipe labelisée Ligue Nationale Contre le Cancer, PSL Research University
Alix Scholer-Dahirel: Institut Curie, Stress and Cancer Laboratory, Equipe labelisée Ligue Nationale Contre le Cancer, PSL Research University
Philemon Sirven: Institut Curie, Integrative Biology of Human Dendritic Cells and T Cells Laboratory, PSL Research University, U932, Inserm
Melissa Cardon: Institut Curie, Stress and Cancer Laboratory, Equipe labelisée Ligue Nationale Contre le Cancer, PSL Research University
Floriane Pelon: Institut Curie, Stress and Cancer Laboratory, Equipe labelisée Ligue Nationale Contre le Cancer, PSL Research University
Ilaria Magagna: Institut Curie, Stress and Cancer Laboratory, Equipe labelisée Ligue Nationale Contre le Cancer, PSL Research University
Géraldine Gentric: Institut Curie, Stress and Cancer Laboratory, Equipe labelisée Ligue Nationale Contre le Cancer, PSL Research University
Ana Costa: Institut Curie, Stress and Cancer Laboratory, Equipe labelisée Ligue Nationale Contre le Cancer, PSL Research University
Claire Bonneau: Institut Curie, Stress and Cancer Laboratory, Equipe labelisée Ligue Nationale Contre le Cancer, PSL Research University
Virginie Mieulet: Institut Curie, Stress and Cancer Laboratory, Equipe labelisée Ligue Nationale Contre le Cancer, PSL Research University
Anne Vincent-Salomon: Department of Pathology, Institut Curie Hospital Group
Fatima Mechta-Grigoriou: Institut Curie, Stress and Cancer Laboratory, Equipe labelisée Ligue Nationale Contre le Cancer, PSL Research University

DOI: https://doi.org/10.1038/s41467-018-03348-z
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 20

Abstract

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Cancer-associated fibroblasts (CAFs) are an important part of the tumor microenvironment. Here the authors characterize four subsets of CAFs across human samples of ovarian cancer subtypes and show in the mesenchymal subtype a specific CAF-S1 population that attracts immunosuppressive Tregs via CXCL12β.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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