Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii

Ewa Bielska; Marta Arch Sisquella; Maha Aldeieg; Charlotte Birch; Eloise J. O’Donoghue; Robin C. May

doi:10.1038/s41467-018-03991-6

Nature Communications (Apr 2018)

Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii

Ewa Bielska,
Marta Arch Sisquella,
Maha Aldeieg,
Charlotte Birch,
Eloise J. O’Donoghue,
Robin C. May

Affiliations

Ewa Bielska: Institute of Microbiology and Infection, School of Biosciences, University of Birmingham
Marta Arch Sisquella: Institut d’ Investigació en Ciències de la Salut Germans Trias i Pujol (IGTP)
Maha Aldeieg: School of Biological Sciences, University of Reading
Charlotte Birch: Institute of Microbiology and Infection, School of Biosciences, University of Birmingham
Eloise J. O’Donoghue: Institute of Microbiology and Infection, School of Biosciences, University of Birmingham
Robin C. May: Institute of Microbiology and Infection, School of Biosciences, University of Birmingham

DOI: https://doi.org/10.1038/s41467-018-03991-6
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 9

Abstract

Read online

Highly virulent cells of the fungal pathogen Cryptococcus gattiigrow rapidly within phagocytes by stimulating the growth of neighbouring fungal cells. Here, Bielska et al. show that this effect is mediated by the release of fungal extracellular vesicles that can be taken up by infected macrophages.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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