BMC Genomics (Mar 2024)

DNA-QLC: an efficient and reliable image encoding scheme for DNA storage

  • Yanfen Zheng,
  • Ben Cao,
  • Xiaokang Zhang,
  • Shuang Cui,
  • Bin Wang,
  • Qiang Zhang

DOI
https://doi.org/10.1186/s12864-024-10178-5
Journal volume & issue
Vol. 25, no. 1
pp. 1 – 10

Abstract

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Abstract Background DNA storage has the advantages of large capacity, long-term stability, and low power consumption relative to other storage mediums, making it a promising new storage medium for multimedia information such as images. However, DNA storage has a low coding density and weak error correction ability. Results To achieve more efficient DNA storage image reconstruction, we propose DNA-QLC (QRes-VAE and Levenshtein code (LC)), which uses the quantized ResNet VAE (QRes-VAE) model and LC for image compression and DNA sequence error correction, thus improving both the coding density and error correction ability. Experimental results show that the DNA-QLC encoding method can not only obtain DNA sequences that meet the combinatorial constraints, but also have a net information density that is 2.4 times higher than DNA Fountain. Furthermore, at a higher error rate (2%), DNA-QLC achieved image reconstruction with an SSIM value of 0.917. Conclusions The results indicate that the DNA-QLC encoding scheme guarantees the efficiency and reliability of the DNA storage system and improves the application potential of DNA storage for multimedia information such as images.

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