Insertion-deletion polymorphism of ACE gene and increased body mass among hypertensive patients from various ethnic groups in Mordovia Republic

Abstract

Aim.To stuffy the association between insertion-deletion (ID) polymorphism of ACE gene and increased body mass (BM) among patients with arterial hypertension (AH), representing various ethnic groups of Mordovia Republic.Material and methods. In total, 295 patients with verified essential AH were examined: 207 Mordovians and 88 Russians. The control group included 221 people: 147 Mordovians and 74 Russians. In all participants, anamnestic, clinical, laboratory, and instrumental examination was performed, including 12-lead electrocardiography, echocardiography, and assessment of ACE gene ID polymorphism.Results. It was demonstrated that higher BM index levels were registered in ID genotype carriers of either ethnicity more frequently, but not significantly.Conclusion.In both Mordovian and Russian patients with AH, no significant association was observed between ACE gene polymorphism and increased MT.

Keywords

• arterial hypertension
• increased body mass
• ace gene