Synthesis of high-titer alka(e)nes in Yarrowia lipolytica is enabled by a discovered mechanism

Jingbo Li; Yongshuo Ma; Nian Liu; Bekir E. Eser; Zheng Guo; Peter Ruhdal Jensen; Gregory Stephanopoulos

doi:10.1038/s41467-020-19995-0

Nature Communications (Dec 2020)

Synthesis of high-titer alka(e)nes in Yarrowia lipolytica is enabled by a discovered mechanism

Jingbo Li,
Yongshuo Ma,
Nian Liu,
Bekir E. Eser,
Zheng Guo,
Peter Ruhdal Jensen,
Gregory Stephanopoulos

Affiliations

Jingbo Li: Department of Chemical Engineering, Massachusetts Institute of Technology
Yongshuo Ma: Department of Chemical Engineering, Massachusetts Institute of Technology
Nian Liu: Department of Chemical Engineering, Massachusetts Institute of Technology
Bekir E. Eser: Department of Engineering, Aarhus University
Zheng Guo: Department of Engineering, Aarhus University
Peter Ruhdal Jensen: National Food Institute, Technical University of Denmark
Gregory Stephanopoulos: Department of Chemical Engineering, Massachusetts Institute of Technology

DOI: https://doi.org/10.1038/s41467-020-19995-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 13

Abstract

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Alka(e)nes with chain lengths in C5-C23 range are ideal fuel components. Here, the authors report that high-titer production of alak(e)nes in pathway engineered Yarrowia lipolytica, which is enabled by the finding that acyl-CoA is another substrate of fatty acid photodecarboxylase (FAP).

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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