Nature Communications (Nov 2021)

Selection for constrained peptides that bind to a single target protein

  • Andrew M. King,
  • Daniel A. Anderson,
  • Emerson Glassey,
  • Thomas H. Segall-Shapiro,
  • Zhengan Zhang,
  • David L. Niquille,
  • Amanda C. Embree,
  • Katelin Pratt,
  • Thomas L. Williams,
  • D. Benjamin Gordon,
  • Christopher A. Voigt

DOI
https://doi.org/10.1038/s41467-021-26350-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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Peptide secondary metabolites have a diverse range of functions. Here the authors present a method to design and screen a large library of modified peptides in E. coli against a target of interest.