Frontiers in Oncology (Aug 2021)

The Emerging Landscapes of Long Noncoding RNA in Thyroid Carcinoma: Biological Functions and Clinical Significance

  • Jian Zhu,
  • Jian Zhu,
  • Changrui Liu,
  • Dan Wang,
  • Xianjiao Cao,
  • Shuai Wang,
  • Yixin Liu,
  • Jun Wang,
  • Peifeng Li,
  • Qingqing He

DOI
https://doi.org/10.3389/fonc.2021.706011
Journal volume & issue
Vol. 11

Abstract

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Thyroid carcinoma (TC) is one of the most prevalent primary endocrine tumors, and its incidence is steadily and gradually increasing worldwide. Accumulating evidence has revealed the critical functions of long noncoding RNAs (lncRNAs) in the tumorigenesis and development of TC. Many TC-associated lncRNAs have been documented to be implicated in TC malignant behaviors, including abnormal cell proliferation, enhanced stem cell properties and aggressiveness, and resistance to therapeutics, through interaction with proteins, DNA, or RNA or encoding small peptides. Therefore, further elucidating the lncRNA dysregulation sheds additional insights into TC tumorigenesis and progression and opens new avenues for the early diagnosis and clinical therapy of TC. In this review, we summarize the abnormal expression of lncRNA in TC and the fundamental characteristics in TC tumorigenesis and development. Additionally, we introduce the potential prognostic and therapeutic significance of lncRNAs in TC.

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