OncoTargets and Therapy (2020-12-01)

Physiological and Pathophysiological Roles of Ion Transporter-Mediated Metabolism in the Thyroid Gland and in Thyroid Cancer

  • Wang H,
  • Ma Z,
  • Cheng X,
  • Tuo B,
  • Liu X,
  • Li T

Journal volume & issue
Vol. Volume 13
pp. 12427 – 12441

Abstract

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Hu Wang,1 Zhiyuan Ma,1 Xiaoming Cheng,1 Biguang Tuo,2,3 Xuemei Liu,2,3 Taolang Li1 1Department of Thyroid and Breast Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, People’s Republic of China; 2Department of Gastroenterology, Affiliated Hospital of Zunyi Medical University, Zunyi, People’s Republic of China; 3Digestive Disease Institute of Guizhou Province, Zunyi, People’s Republic of ChinaCorrespondence: Taolang LiDepartment of Thyroid and Breast Surgery, Affiliated Hospital, Zunyi Medical University, Zunyi 563003, People’s Republic of ChinaEmail [email protected] LiuDepartment of Gastroenterology, Affiliated Hospital, Zunyi Medical University, Zunyi 563003, People’s Republic of ChinaEmail [email protected]: Thyroid cancer is the most common type of endocrine tumor and has shown an increasing annual incidence, especially among women. Patients with thyroid cancer have a good prognosis, with a high five-year survival rate; however, the recurrence rate and disease status of thyroid cancer remain a burden for patients, which compels us to further elucidate the pathogenesis of this disease. Recently, ion transporters have gradually become a hot topic in the field of thyroid gland biology and cancer research. Additionally, alterations in the metabolic state of tumor cells and protein molecules have gradually become the focus of scientific research. This review focuses on the progress in understanding the physiological and pathophysiological roles of ion transporter-mediated metabolism in both the thyroid gland and thyroid cancer. We also hope to shed light on new targets for the treatment and prognosis of thyroid cancer.Keywords: thyroid cancer, metabolism, ion transporters, physiology and pathophysiology, regulation factors

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