Role of immune and metabolic processes in pathogenesis of the development of chronic periodontitis and pneumonia and correction of their impairment with quercetin

Abstract

Chronic periodontitis is one of the most common diseases in dental practice, which shows annual tendency to increase. Nowadays, mechanisms of the formation of this pathology have been substantially studied. However, chronic periodontitis often occurs in combination with a concomitant pathology, in particular, pneumonia. Mechanisms of their formation under conditions of combined pathology and the role of the immune system have not been studied completely, prompting topicality of this research. The results of investigation of the peculiarities of changes in phagocytic leukocyte activity, indices of immune status in the blood, prooxidant and oxidant systems in the periodontium and lungs of guinea pig males in early (6th and 10th days) and late (20th day) periods of chronic periodontitis and in combination with experimental pneumonia have been presented in the article. It has been shown that early and late periods of chronic periodontitis formation, as well as in combination with experimental pneumonia pathology were characterized by increased phagocytic leukocyte activity, which was manifested by an increase (p

Keywords

• chronic periodontitis
• experimental pneumonia
• immune status
• phagocytic leukocyte activity
• antioxidant system
• quercetin.