Nature Communications (Sep 2022)
Expanding the terpene biosynthetic code with non-canonical 16 carbon atom building blocks
- Codruta Ignea,
- Morten H. Raadam,
- Aikaterini Koutsaviti,
- Yong Zhao,
- Yao-Tao Duan,
- Maria Harizani,
- Karel Miettinen,
- Panagiota Georgantea,
- Mads Rosenfeldt,
- Sara E. Viejo-Ledesma,
- Mikael A. Petersen,
- Wender L. P. Bredie,
- Dan Staerk,
- Vassilios Roussis,
- Efstathia Ioannou,
- Sotirios C. Kampranis
Affiliations
- Codruta Ignea
- Biochemical Engineering Group, Plant Biochemistry Section, Department of Plant and Environmental Sciences, University of Copenhagen
- Morten H. Raadam
- Biochemical Engineering Group, Plant Biochemistry Section, Department of Plant and Environmental Sciences, University of Copenhagen
- Aikaterini Koutsaviti
- Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens
- Yong Zhao
- Biochemical Engineering Group, Plant Biochemistry Section, Department of Plant and Environmental Sciences, University of Copenhagen
- Yao-Tao Duan
- Biochemical Engineering Group, Plant Biochemistry Section, Department of Plant and Environmental Sciences, University of Copenhagen
- Maria Harizani
- Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens
- Karel Miettinen
- Biochemical Engineering Group, Plant Biochemistry Section, Department of Plant and Environmental Sciences, University of Copenhagen
- Panagiota Georgantea
- Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens
- Mads Rosenfeldt
- Biochemical Engineering Group, Plant Biochemistry Section, Department of Plant and Environmental Sciences, University of Copenhagen
- Sara E. Viejo-Ledesma
- Biochemical Engineering Group, Plant Biochemistry Section, Department of Plant and Environmental Sciences, University of Copenhagen
- Mikael A. Petersen
- Department of Food Science, University of Copenhagen
- Wender L. P. Bredie
- Department of Food Science, University of Copenhagen
- Dan Staerk
- Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen
- Vassilios Roussis
- Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens
- Efstathia Ioannou
- Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens
- Sotirios C. Kampranis
- Biochemical Engineering Group, Plant Biochemistry Section, Department of Plant and Environmental Sciences, University of Copenhagen
- DOI
- https://doi.org/10.1038/s41467-022-32921-w
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 16
Abstract
Establishing methods to access the chemical space that lies beyond canonical terpenoid biosynthesis will increase the applications of isoprenoids. Here, the authors reconstruct the modular structure of terpene biosynthesis on 16-carbon backbones by engineered yeast and synthesize 28 different unique terpenes.
