Four New Picrotoxane-Type Sesquiterpenes From Dendrobium nobile Lindl

Pei Wang; Xin Chen; Xin Chen; Hao Wang; Shengzhuo Huang; Caihong Cai; Jingzhe Yuan; Guoliang Zhu; Xinglian Xu; Wenli Mei; Haofu Dai

doi:10.3389/fchem.2019.00812

Frontiers in Chemistry (Nov 2019)

Four New Picrotoxane-Type Sesquiterpenes From Dendrobium nobile Lindl

Pei Wang,
Xin Chen,
Xin Chen,
Hao Wang,
Shengzhuo Huang,
Caihong Cai,
Jingzhe Yuan,
Guoliang Zhu,
Xinglian Xu,
Wenli Mei,
Haofu Dai

Affiliations

Pei Wang: Hainan Key Laboratory of Research and Development of Natural Product From Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
Xin Chen: Hainan Key Laboratory of Research and Development of Natural Product From Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
Xin Chen: Nanjing Agricultural University, Nanjing, China
Hao Wang: Hainan Key Laboratory of Research and Development of Natural Product From Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
Shengzhuo Huang: Hainan Key Laboratory of Research and Development of Natural Product From Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
Caihong Cai: Hainan Key Laboratory of Research and Development of Natural Product From Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
Jingzhe Yuan: Hainan Key Laboratory of Research and Development of Natural Product From Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
Guoliang Zhu: East China University of Science and Technology, Shanghai, China
Xinglian Xu: Nanjing Agricultural University, Nanjing, China
Wenli Mei: Hainan Key Laboratory of Research and Development of Natural Product From Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China
Haofu Dai: Hainan Key Laboratory of Research and Development of Natural Product From Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou, China

DOI: https://doi.org/10.3389/fchem.2019.00812
Journal volume & issue: Vol. 7

Abstract

Read online

Four picrotoxane-type sesquiterpenes, dendroterpene A–D (1–4), together with four known compounds (5–8), were isolated from the stems of Dendrobium nobile Lindl. Their structures were elucidated by spectroscopic analysis, X-ray diffraction analysis, analysis of the ECD data according to the Klyne's lactone sector rule, and quantum ECD calculation. Compounds 1 and 2 are two new picrotoxane-type sesquiterpenes with a new carbon skeleton containing a formamide group, which may be derived from the previously reported dendrobiumane B skeleton by the C(9)-C(11) carbon bond cleavage. Compounds 3, 5, 6, and 8 exhibited inhibitory activity against α-glycosidase. Compounds 5 and 6 were cytotoxic against SGC-7901, K562, A549, BEL-7402, and Hela cell lines.

Published in Frontiers in Chemistry

ISSN: 2296-2646 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Chemistry
Website: http://journal.frontiersin.org/journal/chemistry

About the journal

Abstract

Keywords