International Journal of Nanomedicine (Sep 2022)
Polysaccharide Electrospun Nanofibers for Wound Healing Applications
Abstract
Guoxin Tan,1 Lijie Wang,2 Weisan Pan,3 Kai Chen4 1School of Pharmacy, Hainan University, Haikou, 570228, People’s Republic of China; 2School of Pharmacy, Shenyang Medical College, Shenyang, 110034, People’s Republic of China; 3School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, People’s Republic of China; 4Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, People’s Republic of ChinaCorrespondence: Kai Chen, Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, People’s Republic of China, Tel/Fax +86 898-66890907, Email [email protected]: As a type of biological macromolecule, natural polysaccharides have been widely used in wound healing due to their low toxicity, good biocompatibility, degradability and reproducibility. Electrospinning is a versatile and simple technique for producing continuous nanoscale fibers from a variety of natural and synthetic polymers. The application of electrospun nanofibers as wound dressings has made great progress and they are considered one of the most effective wound dressings. This paper reviews the preparation of polysaccharide nanofibers by electrospinning and their application prospects in the field of wound healing. A variety of polysaccharide nanofibers, including chitosan, starch, alginate, and hyaluronic acid are introduced. The preparation strategy of polysaccharide electrospun nanofibers and their functions in promoting wound healing are summarized. In addition, the future prospects and challenges for the preparation of polysaccharide nanofibers by electrospinning are also discussed.Keywords: polysaccharide, electrospun nanofibers, wound healing, preparation strategy, function
