Hierarchical control of enzymatic actuators using DNA-based switchable memories

Lenny H. H. Meijer; Alex Joesaar; Erik Steur; Wouter Engelen; Rutger A. van Santen; Maarten Merkx; Tom F. A. de Greef

doi:10.1038/s41467-017-01127-w

Nature Communications (Oct 2017)

Hierarchical control of enzymatic actuators using DNA-based switchable memories

Lenny H. H. Meijer,
Alex Joesaar,
Erik Steur,
Wouter Engelen,
Rutger A. van Santen,
Maarten Merkx,
Tom F. A. de Greef

Affiliations

Lenny H. H. Meijer: Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology
Alex Joesaar: Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology
Erik Steur: Institute for Complex Molecular Systems, Eindhoven University of Technology
Wouter Engelen: Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology
Rutger A. van Santen: Institute for Complex Molecular Systems, Eindhoven University of Technology
Maarten Merkx: Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology
Tom F. A. de Greef: Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology

DOI: https://doi.org/10.1038/s41467-017-01127-w
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Naturally evolved regulatory circuits have hierarchical layers of signal generation and processing. Here, the authors emulate these networks using feedback-controlled DNA circuits that convert upstream signaling to downstream enzyme activity in a switchable memories circuit.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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