Nature Communications (Jul 2017)

Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

  • Carl A. Machutta,
  • Christopher S. Kollmann,
  • Kenneth E. Lind,
  • Xiaopeng Bai,
  • Pan F. Chan,
  • Jianzhong Huang,
  • Lluis Ballell,
  • Svetlana Belyanskaya,
  • Gurdyal S. Besra,
  • David Barros-Aguirre,
  • Robert H. Bates,
  • Paolo A. Centrella,
  • Sandy S. Chang,
  • Jing Chai,
  • Anthony E. Choudhry,
  • Aaron Coffin,
  • Christopher P. Davie,
  • Hongfeng Deng,
  • Jianghe Deng,
  • Yun Ding,
  • Jason W. Dodson,
  • David T. Fosbenner,
  • Enoch N. Gao,
  • Taylor L. Graham,
  • Todd L. Graybill,
  • Karen Ingraham,
  • Walter P. Johnson,
  • Bryan W. King,
  • Christopher R. Kwiatkowski,
  • Joël Lelièvre,
  • Yue Li,
  • Xiaorong Liu,
  • Quinn Lu,
  • Ruth Lehr,
  • Alfonso Mendoza-Losana,
  • John Martin,
  • Lynn McCloskey,
  • Patti McCormick,
  • Heather P. O’Keefe,
  • Thomas O’Keeffe,
  • Christina Pao,
  • Christopher B. Phelps,
  • Hongwei Qi,
  • Keith Rafferty,
  • Genaro S. Scavello,
  • Matt S. Steiginga,
  • Flora S. Sundersingh,
  • Sharon M. Sweitzer,
  • Lawrence M. Szewczuk,
  • Amy Taylor,
  • May Fern Toh,
  • Juan Wang,
  • Minghui Wang,
  • Devan J. Wilkins,
  • Bing Xia,
  • Gang Yao,
  • Jean Zhang,
  • Jingye Zhou,
  • Christine P. Donahue,
  • Jeffrey A. Messer,
  • David Holmes,
  • Christopher C. Arico-Muendel,
  • Andrew J. Pope,
  • Jeffrey W. Gross,
  • Ghotas Evindar

DOI
https://doi.org/10.1038/ncomms16081
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

Read online

Encoded Library Technology (ELT) has streamlined the identification of chemical ligands for protein targets in drug discovery. Here, the authors optimize the ELT approach to screen multiple proteins in parallel and identify promising targets and antibacterial compounds forS. aureus, A. baumannii and M. tuberculosis.