Intraocular Pressure (IOP) in Patients with Acromegaly versus Healthy Controls: A Systematic Review and Meta-Analysis

Abstract

Purpose. Acromegaly is an uncommon condition but affects numerous organ systems. It has been found that patients with acromegaly can experience ocular changes, such as raised intraocular pressure (IOP). Numerous studies have since been carried out to determine whether there is a significant difference between IOP in patients with acromegaly and healthy controls and there is much disagreement in the literature. This study aims to perform a systematic review and meta-analysis to establish whether there is a significant difference in IOP between the two groups in a larger population. Methods. A systematic literature search was performed using PubMed, Scopus, and Web of Science to access relevant databases and to locate outcome studies. Eligibility criteria included type of publication, participant characteristics, and report of outcomes. Data analysis was conducted with a fixed-effects model. Results. Three articles were included in the final analysis. The mean value of IOP corrected for central corneal thickness (IOPcc) for the group of 102 patients with acromegaly was 15.33 with confidence levels of 13.05–17.62 [mmHg]. The mean difference between the control and acromegaly group was 1.17 with confidence levels of 0.64 to 1.70 [mmHg], which was found to be statistically significant (p < 0.001). Conclusion. The results of the meta-analysis indicate that acromegaly is associated with increased IOP. As raised IOP is a risk factor for the development of glaucoma, detailed IOPcc evaluation should be an important procedure in the follow-up visits of patients with acromegaly.

Keywords

• intraocular pressure
• acromegaly
• meta-analysis
• systematic review