Frontiers in Neuroscience (May 2025)
Brain organoid model systems of neurodegenerative diseases: recent progress and future prospects
- Saniyah Shaikh,
- Luqman Siddique,
- Hafsah T. Khalifey,
- Rutaba Mahereen,
- Thaabit Raziq,
- Rushdan M. Firdous,
- Aisha Siddique,
- Aisha Siddique,
- Aisha Siddique,
- Ismail M. Shakir,
- Ismail M. Shakir,
- Ismail M. Shakir,
- Zara Ahmed,
- Arshiya Akbar,
- Eman A. Alshehri,
- Raja Chinappan,
- Raja Chinappan,
- Alaa Alzhrani,
- Alaa Alzhrani,
- Alaa Alzhrani,
- Tanveer Ahmed Mir,
- Tanveer Ahmed Mir,
- Ahmed Yaqinuddin
Affiliations
- Saniyah Shaikh
- College of Medicine, Alfaisal University, Riyadh, Saudi Arabia
- Luqman Siddique
- College of Medicine, Alfaisal University, Riyadh, Saudi Arabia
- Hafsah T. Khalifey
- College of Medicine, Alfaisal University, Riyadh, Saudi Arabia
- Rutaba Mahereen
- College of Medicine, Alfaisal University, Riyadh, Saudi Arabia
- Thaabit Raziq
- College of Medicine, Alfaisal University, Riyadh, Saudi Arabia
- Rushdan M. Firdous
- College of Medicine, Alfaisal University, Riyadh, Saudi Arabia
- Aisha Siddique
- College of Medicine, Alfaisal University, Riyadh, Saudi Arabia
- Aisha Siddique
- Bioscience Program, Biological and Environmental Science and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia
- Aisha Siddique
- KAUST Center of Excellence for Smart Health (KCSH), Thuwal, Saudi Arabia
- Ismail M. Shakir
- College of Medicine, Alfaisal University, Riyadh, Saudi Arabia
- Ismail M. Shakir
- Bioscience Program, Biological and Environmental Science and Engineering Division (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia
- Ismail M. Shakir
- KAUST Center of Excellence for Smart Health (KCSH), Thuwal, Saudi Arabia
- Zara Ahmed
- College of Medicine, Alfaisal University, Riyadh, Saudi Arabia
- Arshiya Akbar
- Shadan Degree and P.G. College for Women, Osmania University, Hyderabad, India
- Eman A. Alshehri
- Tissue/Organ Bioengineering and BioMEMS Lab, Organ Transplant Centre of Excellence (TR&I Dept), King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
- Raja Chinappan
- College of Medicine, Alfaisal University, Riyadh, Saudi Arabia
- Raja Chinappan
- Tissue/Organ Bioengineering and BioMEMS Lab, Organ Transplant Centre of Excellence (TR&I Dept), King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
- Alaa Alzhrani
- College of Medicine, Alfaisal University, Riyadh, Saudi Arabia
- Alaa Alzhrani
- Tissue/Organ Bioengineering and BioMEMS Lab, Organ Transplant Centre of Excellence (TR&I Dept), King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
- Alaa Alzhrani
- Department of Medical Laboratory Technology, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, Saudi Arabia
- Tanveer Ahmed Mir
- College of Medicine, Alfaisal University, Riyadh, Saudi Arabia
- Tanveer Ahmed Mir
- Tissue/Organ Bioengineering and BioMEMS Lab, Organ Transplant Centre of Excellence (TR&I Dept), King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
- Ahmed Yaqinuddin
- College of Medicine, Alfaisal University, Riyadh, Saudi Arabia
- DOI
- https://doi.org/10.3389/fnins.2025.1604435
- Journal volume & issue
-
Vol. 19
Abstract
Neurological diseases are a leading cause of disability, morbidity, and mortality, affecting 43% of the world’s population. The detailed study of neurological diseases, testing of drugs, and repair of site-specific defects require physiologically relevant models that recapitulate key events and dynamic neurodevelopmental processes in a highly organized fashion. As an evolving technology, self-organizing and self-assembling brain organoids offer the advantage of modeling different stages of brain development in a 3D microenvironment. Herein, we review the utility, advantages, and limitations of the latest breakthroughs in brain organoid endeavors in the context of modeling three of the most prevalent neurodegenerative diseases—Alzheimer’s, Parkinson’s, and Huntington’s disease. We conclude the review with a perspective on the future prospects of brain organoid models with their myriad possible applications in translational medicine.
Keywords
