The role of RNF149 in the pre-emptive quality control substrate ubiquitination

Aster Legesse; Nathali Kaushansky; Ilana Braunstein; Haddas Saad; Gerardo Lederkremer; Ami Navon; Ariel Stanhill

doi:10.1038/s42003-023-04763-9

Communications Biology (Apr 2023)

The role of RNF149 in the pre-emptive quality control substrate ubiquitination

Aster Legesse,
Nathali Kaushansky,
Ilana Braunstein,
Haddas Saad,
Gerardo Lederkremer,
Ami Navon,
Ariel Stanhill

Affiliations

Aster Legesse: Department of Natural and Life Sciences, Open University of Israel
Nathali Kaushansky: Department of Molecular Cell Biology, Weizmann institute of Science
Ilana Braunstein: Department of Biochemistry, Technion School of Medicine
Haddas Saad: The Shmunis School of Biomedicine and Cancer Research, George Wise Faculty of Life Sciences, Tel-Aviv University
Gerardo Lederkremer: The Shmunis School of Biomedicine and Cancer Research, George Wise Faculty of Life Sciences, Tel-Aviv University
Ami Navon: Department of Immunology and Regenerative Biology, Weizmann institute of Science
Ariel Stanhill: Department of Natural and Life Sciences, Open University of Israel

DOI: https://doi.org/10.1038/s42003-023-04763-9
Journal volume & issue: Vol. 6, no. 1
pp. 1 – 10

Abstract

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E3 ligase RNF149 contributes to the pre-emptive quality control (pQC) pathway & interacts with AIRAPL in a ubiquitin-dependent manner, with loss of RNF149 function appearing to increase the translocation flux of pQC substrates to the ER.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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