Frontiers in Neurology (Oct 2024)
Bipolar and Laplacian montages are suitable for high-gamma modulation language mapping with stereoelectroencephalography
Abstract
ObjectiveTo determine the optimal montage and vocalization conditions for high-gamma language mapping using stereoelectroencephalography.MethodsWe studied 12 epilepsy patients who underwent invasive monitoring with depth electrodes and measurement of auditory-naming related high-gamma modulations. We determined the effects of electrode montage and vocalization conditions of the response on the high-gamma (60–140 Hz) amplitudes.ResultsCompared to common average reference montage, bipolar and Laplacian montages effectively reduced the degree of auditory naming-related signal deflections in the white matter during the stimulus and response phases (mixed model estimate: −21.2 to −85.4%; p < 0.001), while maintaining those at the cortical level (−4.4 to +7.8%; p = 0.614 to 0.085). They also reduced signal deflections outside the brain parenchyma during the response phase (−90.6 to −91.2%; p < 0.001). Covert responses reduced signal deflections outside the brain parenchyma during the response phase (−17.0%; p = 0.010).ConclusionOn depth electrode recording, bipolar and Laplacian montages are suitable for measuring auditory naming-related high-gamma modulations in gray matter. The covert response may highlight the gray matter activity.SignificanceThis study helps establish the practical guidelines for high-gamma language mapping using stereoelectroencephalography.
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