Nature Communications (Oct 2017)
Regulation of endothelial intracellular adenosine via adenosine kinase epigenetically modulates vascular inflammation
- Yiming Xu,
- Yong Wang,
- Siyuan Yan,
- Qiuhua Yang,
- Yaqi Zhou,
- Xianqiu Zeng,
- Zhiping Liu,
- Xiaofei An,
- Haroldo A. Toque,
- Zheng Dong,
- Xuejun Jiang,
- David J. Fulton,
- Neal L. Weintraub,
- Qinkai Li,
- Zsolt Bagi,
- Mei Hong,
- Detlev Boison,
- Chaodong Wu,
- Yuqing Huo
Affiliations
- Yiming Xu
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Yong Wang
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Siyuan Yan
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Qiuhua Yang
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Yaqi Zhou
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Xianqiu Zeng
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Zhiping Liu
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Xiaofei An
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Haroldo A. Toque
- Department of Pharmacology and Toxicology, Augusta University
- Zheng Dong
- Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Xuejun Jiang
- State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Science
- David J. Fulton
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Neal L. Weintraub
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Qinkai Li
- Drug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School
- Zsolt Bagi
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- Mei Hong
- Drug Discovery Center, Key Laboratory of Chemical Genomics, Peking University Shenzhen Graduate School
- Detlev Boison
- Robert S. Dow Neurobiology Laboratories, Legacy Research Institute
- Chaodong Wu
- Department of Nutrition and Food Science, Texas A&M University
- Yuqing Huo
- Vascular Biology Center, Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University
- DOI
- https://doi.org/10.1038/s41467-017-00986-7
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 16
Abstract
The molecular mechanisms underlying vascular inflammation are unclear. Here the authors show that pro-inflammatory stimuli lead to endothelial inflammation by increasing adenosine kinase expression, and that its knockdown in endothelial cells inhibits atherosclerosis and cerebral ischemic injury in mice.
