Prescription drugs with potential for misuse: protocol for a multi-indicator analysis of supply, detection and the associated health burden in Ireland between 2010 and 2020
Gráinne Cousins,
Kathleen E Bennett,
Paul Corcoran,
Ella Arensman,
Eamon Keenan,
Suzi Lyons,
Louise Durand,
Aoife O’Kane,
Julie Tierney,
Richard Maguire,
Siobhán Stokes,
Deirdre O’Reilly,
María Otero Vázquez,
Yvonne Kavanagh
Affiliations
Gráinne Cousins
School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences, Dublin, Ireland
Kathleen E Bennett
Data Science Centre, Population Health Sciences, Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences, Dublin, Ireland
Paul Corcoran
National Suicide Research Foundation, School of Public Health, University College Cork, Cork, Ireland
Ella Arensman
National Suicide Research Foundation, School of Public Health, University College Cork, Cork, Ireland
Eamon Keenan
National Social Inclusion Office, Health Service Executive, Dublin, Ireland
Suzi Lyons
National Health Information Systems, Health Research Board, Dublin, Ireland
Louise Durand
School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences, Dublin, Ireland
Aoife O’Kane
School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland (RCSI) University of Medicine and Health Sciences, Dublin, Ireland
Julie Tierney
Forensic Toxicology, The State Laboratory, Kildare, Ireland
Richard Maguire
Medical Bureau of Road Safety, Health Science Centre, University College Dublin, Dublin, Ireland
Siobhán Stokes
National Drug Treatment Centre, Health Service Executive, Dublin, Ireland
Introduction There is an increasing concern about the misuse of prescription drugs. Misuse refers to the intentional repurposing of prescribed drugs and/or the use of illicitly sourced prescription drugs, which may be counterfeit or contaminated. Drugs with the greatest potential for misuse are prescription opioids, gabapentinoids, benzodiazepines, Z-drugs and stimulants.Objective The aim of this study is to provide a comprehensive analysis of the supply, patterns of use and health burden associated with prescription drugs with potential for misuse (PDPM) in Ireland between 2010 and 2020. Three inter-related studies will be carried out. The first study will describe trends in supply of PDPM using law enforcement drug seizures data and national prescription records from national community and prison settings. The second study aims to estimate trends in the detection of PDPM across multiple early warning systems using national forensic toxicology data. The third study aims to quantify the health burden associated with PDPM nationally, using epidemiological indicators of drug-poisoning deaths, non-fatal intentional drug overdose presentations to hospitals and drug treatment demand.Methods and analysis A retrospective observational study design, with repeated cross-sectional analyses, using negative binomial regression models or, where appropriate, joinpoint regression.Ethics and dissemination The study has received approval from the RCSI Ethics Committee (REC202202020). Results will be disseminated in peer-reviewed journals, scientific and drug policy meetings and with key stakeholders via research briefs.
