Nature Communications (Oct 2017)
PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation
Abstract
In colorectal cancer, EGFR signalling is implicated in metastasis. Here, the authors unravel a mechanism through which EGF stimulation induces MIIP phosphorylation, leading to MIIP interacting with RelA—this prevents RelA deactylation and enhances transcriptional activity, facilitating metastasis.