Nature Communications (Oct 2017)

PKCε phosphorylates MIIP and promotes colorectal cancer metastasis through inhibition of RelA deacetylation

  • Tao Chen,
  • Jingjie Li,
  • Meidong Xu,
  • Qin Zhao,
  • Yingyong Hou,
  • Liqing Yao,
  • Yunshi Zhong,
  • Ping-Chieh Chou,
  • Wei Zhang,
  • Pinghong Zhou,
  • Yuhui Jiang

DOI
https://doi.org/10.1038/s41467-017-01024-2
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

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In colorectal cancer, EGFR signalling is implicated in metastasis. Here, the authors unravel a mechanism through which EGF stimulation induces MIIP phosphorylation, leading to MIIP interacting with RelA—this prevents RelA deactylation and enhances transcriptional activity, facilitating metastasis.