Nature Communications (Dec 2022)

Visualizing the transiently populated closed-state of human HSP90 ATP binding domain

  • Faustine Henot,
  • Elisa Rioual,
  • Adrien Favier,
  • Pavel Macek,
  • Elodie Crublet,
  • Pierre Josso,
  • Bernhard Brutscher,
  • Matthias Frech,
  • Pierre Gans,
  • Claire Loison,
  • Jerome Boisbouvier

DOI
https://doi.org/10.1038/s41467-022-35399-8
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 13

Abstract

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To refold client proteins, HSP90 chaperone undergoes large structural rearrangements. Here the authors use NMR and molecular simulation and reveal structure and dynamics of a key functionally relevant metastable state of human HSP90α N-terminal domain.