Development and challenges of cells- and materials-based tooth regeneration

Zeyu Fu; Yu Zhuang; Jinjie Cui; Ruilong Sheng; Helena Tomás; João Rodrigues; Bin Zhao; Xudong Wang; Kaili Lin

Engineered Regeneration (Jun 2022)

Development and challenges of cells- and materials-based tooth regeneration

Zeyu Fu,
Yu Zhuang,
Jinjie Cui,
Ruilong Sheng,
Helena Tomás,
João Rodrigues,
Bin Zhao,
Xudong Wang,
Kaili Lin

Affiliations

Zeyu Fu: Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai 200011, China; School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China
Yu Zhuang: Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai 200011, China
Jinjie Cui: Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai 200011, China
Ruilong Sheng: CQM-Centro de Quimica da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Madeira, Portugal
Helena Tomás: CQM-Centro de Quimica da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Madeira, Portugal
João Rodrigues: CQM-Centro de Quimica da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Madeira, Portugal; School of Materials Science and Engineering, Center for Nano Energy Materials, Northwestern Polytechnical University, Xi'an, 710072, China
Bin Zhao: School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China; Corresponding author.
Xudong Wang: Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai 200011, China; Corresponding author.
Kaili Lin: Department of Oral and Cranio-Maxillofacial Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology; Research Unit of Oral and Maxillofacial Regenerative Medicine, Chinese Academy of Medical Sciences, Shanghai 200011, China; Corresponding author.

Journal volume & issue: Vol. 3, no. 2
pp. 163 – 181

Abstract

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Tooth defect and loss are common clinical diseases in stomatology. With the extension of life expectancy, there is an increasing demand for tooth tissue and whole tooth regeneration. Compared with traditional oral prosthetic treatment, tooth regeneration has unique advantages and has become one of the hotspots towards oral biomedical treatment. In this review, we discussed the development and challenges of tooth regeneration based on cells and materials, including tooth enamel, dentin, dental pulp, cementum, dentin-pulp complex, and the whole tooth regeneration, in order to provide a comprehensive, up-to-date, illustrative overview of tooth regeneration issues. The mechanisms of the regeneration were also summarized and discussed. Moreover, this review hints the future perspective and research direction of tooth regeneration in the challenging field of regenerative dentistry.

Published in Engineered Regeneration

ISSN: 2666-1381 (Online)
Publisher: KeAi Communications Co., Ltd.
Country of publisher: China
LCC subjects: Science: Biology (General): Life
Website: https://www.keaipublishing.com/en/journals/engineered-regeneration/

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