Ethical Principles and Rules in Experimental Animal Studies: A Comprehensive Review

Abstract

When doing scientific research including animal experiments, it is crucial to prioritize ethical issues due to the many moral, legal, and scientific aspects involved. This study provides an in-depth analysis of the core ethical concepts and regulations that govern experimental investigations using animals. The 3R principle (replacement, reduction, refinement), which prioritizes the ethical treatment of animals especially in scientific research, is emphasized. Tracing the historical development of ethical rules sheds light on the important events that shaped the creation of important principles. The review examines the complex relationship between scientific investigation and ethical concerns, focusing on the idea of informed consent in relation to animal care. Also, this explores the ethical dilemmas that arise from experimental techniques and sheds light on how researchers ensure the well-being of the animals involved. The crucial importance of an ethical committee is emphasized in guaranteeing strict ethical standards. The examination of ethical concerns related to certain animal models, and analysis of differing perspectives among the scientific community is done. At the same time, it examines the latest developments in experimental animal research, providing insight into the future of ethical issues in this ever-evolving area. To summarize, this review not only synthesizes the main discoveries and ethical concerns in experimental animal studies but also highlights potential future paths. It supports the idea of continuing to balance scientific progress in the field of experimental animal studies with ethical obligations by suggesting additional areas of research and ethical review.