COMPARABLE PHARMACODYNAMICS OF TRADITIONAL AND RECTAL APPLICATION OF THE AMLODIPINE IN PATIENTS WITH ARTERIAL HYPERTENSION WITH HIGH RISK OF CEREBROVASCULAR COMPLICATIONS

Abstract

Evaluation of the antihypertensive efficiency of 10 mg amlodipin rectal suppositories monotherapy of grade 2 arterial hypertension with brachiocephalic artery atherosclerosis in comparison with 10 mg amlodipin tablets during 4 weeks was carried out. It was established that amlodipin rectal suppositopies significant decrease systolic and diastolic arterial pressure and normalize its variability. Also linear rate asymmetry of carotid arterial blood flow essential decreases that indicates increase of brain perfusion. Rising of daily hypotensive activity uniformity after application of amlodipin rectal dosage form in comparison with tablet was determined. Side reactions and undesirable effects throughout amlodipin use for both dosage forms wasn't noted.

Keywords

• амлодипин
• суппозитории ректальные
• артериальная гипертензия
• суточное мониторирование артериального давления
• amlodipin
• rectal suppositories
• arterial hypertension
• daily arterial pressure monitoring