Alleviation of diabetic complications by ginsenoside Rg3-enriched red ginseng extract in western diet-fed LDL–/– mice

Evelyn Saba; Seung-Hyung Kim; Sung-Dae Kim; Sang-Joon Park; Dongmi Kwak; Jun-Hwan Oh; Chae-Kyu Park; Man Hee Rhee

Journal of Ginseng Research (Jul 2018)

Alleviation of diabetic complications by ginsenoside Rg3-enriched red ginseng extract in western diet-fed LDL–/– mice

Evelyn Saba,
Seung-Hyung Kim,
Sung-Dae Kim,
Sang-Joon Park,
Dongmi Kwak,
Jun-Hwan Oh,
Chae-Kyu Park,
Man Hee Rhee

Affiliations

Evelyn Saba: Department of Veterinary Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
Seung-Hyung Kim: Institute of Traditional Medicine & Bioscience, Daejeon University, Daejeon, Republic of Korea
Sung-Dae Kim: Research Center, Dongnam Institute of Radiological and Medical Sciences, Busan, Republic of Korea
Sang-Joon Park: Department of Veterinary Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
Dongmi Kwak: Department of Veterinary Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea
Jun-Hwan Oh: R&D Headquarters, Korean Ginseng Corporation, Daejeon, Republic of Korea
Chae-Kyu Park: R&D Headquarters, Korean Ginseng Corporation, Daejeon, Republic of Korea
Man Hee Rhee: Department of Veterinary Medicine, College of Veterinary Medicine, Kyungpook National University, Daegu, Republic of Korea; Corresponding author. Laboratory of Physiology and Cell Signaling, College of Veterinary Medicine, Kyungpook National University, Daegu 41566, Republic of Korea.

Journal volume & issue: Vol. 42, no. 3
pp. 352 – 355

Abstract

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In this study, we precisely showed how the Rg3-enriched red ginseng extract (Rg3-RGE) lowers glucose, triglyceride, and low-density lipoprotein (LDL) levels in LDL–/– mice. Aspartate aminotransferase/serum glutamic-oxaloacetic transaminase), alanine aminotransferase /serum glutamate-pyruvate transaminase, and steatohepatitis were found to be reduced, and atheroma formation was inhibited by Rg3-enriched red ginseng extract. Keywords: antiatheromatic, antidiabetic, antihypercholesterolemic, Rg3-enriched Korean Red Ginseng extract

Published in Journal of Ginseng Research

ISSN: 1226-8453 (Print)
Publisher: Elsevier
Country of publisher: Korea, Republic of
LCC subjects: Science: Botany
Website: http://www.journals.elsevier.com/journal-of-ginseng-research/

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